Soft tissue tumors are a relatively rare and diagnostically challenging group of neoplasms
that can have varying lines of differentiation. Accurate diagnosis is important for appropriate …

Bone tumors are a rare and heterogeneous group of neoplasms that occur in the bone. The
diversity and considerable morphologic overlap of bone tumors with other mesenchymal …

Highlights•This Clinical Practice Guideline provides key recommendations on the
management of bone sarcomas.•Recommendations have been agreed following a …

Sarcoma represents a highly heterogeneous group of tumours. We report here the first
unbiased and systematic search for gene fusions combined with unsupervised expression …

Ewing sarcoma (ES) and Ewing-like sarcomas are highly aggressive round cell
mesenchymal neoplasms, most often occurring in children and young adults. The …

Abstract BCOR-CCNB3 sarcoma (BCS) is a recently defined genetic entity among
undifferentiated round cell sarcomas, which was initially classified as and treated similarly to …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

With the advent of next-generation sequencing, an increasing number of novel gene fusions
and other abnormalities have emerged recently in the spectrum of EWSR1-negative small …

BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell
differentiation and body structure development and takes part in the noncanonical polycomb …

Aims Infantile fibrosarcoma is characterised by intersecting fascicles of spindle cells and
ETV 6–NTRK 3 gene fusion in most cases. Given histological overlap with other spindle‐cell …