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Structural insights into the biological functions of the long pentraxin PTX3
AM Massimino, FE Colella, B Bottazzi… - Frontiers in …, 2023 - frontiersin.org
Soluble pattern recognition molecules (PRMs) are a heterogenous group of proteins that
recognize pathogen-and danger-associated molecular patterns (PAMPs and DAMPs …
recognize pathogen-and danger-associated molecular patterns (PAMPs and DAMPs …
[HTML][HTML] Mesenchymal Stem Cells and Their Extracellular Vesicles Are a Promising Alternative to Antibiotics for Treating Sepsis
Y Jiang, Y Song, Q Zeng, B Jiang - Bioengineering, 2024 - mdpi.com
Sepsis is a life-threatening disease caused by the overwhelming response to pathogen
infections. Currently, treatment options for sepsis are limited to broad-spectrum antibiotics …
infections. Currently, treatment options for sepsis are limited to broad-spectrum antibiotics …
Modulation of diabetes-related retinal pathophysiology by PTX3
Diabetic retinopathy (DR) is a common complication of diabetes characterized by vascular
pathology and neuroinflammation. Pentraxin 3 (PTX3) is a soluble pattern recognition …
pathology and neuroinflammation. Pentraxin 3 (PTX3) is a soluble pattern recognition …
Pentraxin 3 exacerbates psoriasiform dermatitis through regulation of macrophage polarization
J Liu, C Qiu, Z Zhou, J Li, Y Zhen, R Wang… - International …, 2024 - Elsevier
Objective To elucidate the mechanism of Pentraxin 3 (PTX3) in the pathogenesis of
psoriasiform dermatitis using Ptx3-knockout (Ptx3-KO) background mice. Methods An …
psoriasiform dermatitis using Ptx3-knockout (Ptx3-KO) background mice. Methods An …
[HTML][HTML] PTX3 is expressed in terminal lymphatics and shapes their organization and function
A Doni, M Sironi, A Del Prete… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Introduction The lymphatic system is a multifaceted regulator of tissue homeostasis and an
integral part of immune responses. Previous studies had shown that subsets of lymphatic …
integral part of immune responses. Previous studies had shown that subsets of lymphatic …
[HTML][HTML] Genetic Deficiency of the Long Pentraxin 3 Affects Osteogenesis and Osteoclastogenesis in Homeostatic and Inflammatory Conditions
V Granata, D Strina, ML Schiavone, B Bottazzi… - International Journal of …, 2023 - mdpi.com
The long pentraxin 3 (PTX3) is a soluble glycoprotein made by immune and nonimmune
cells endowed with pleiotropic functions in innate immunity, inflammation, and tissue …
cells endowed with pleiotropic functions in innate immunity, inflammation, and tissue …
PTX3 promotes IVIG resistance-induced endothelial injury in Kawasaki disease by regulating the NF-κB pathway
Y Sun, L Liu, R Yang - Open Life Sciences, 2023 - degruyter.com
Intravenous immunoglobulin (IVIG) resistance leads to serious complications in Kawasaki
disease (KD) with no effective treatment. This study aimed to investigate the effects of …
disease (KD) with no effective treatment. This study aimed to investigate the effects of …
The natural immune molecules urinary Tamm–Horsfall protein and pentraxin 3 as predictors for recurrent urinary tract infection severity: a single-center self-control …
Z Li, Y Xu, Q Wang, G Yuan, J Shu, S Liu, X Gong - Renal Failure, 2025 - Taylor & Francis
Objective The innate immune defense plays a pivotal role in protecting the urinary tract from
uropathogenic invasion and maintaining immune homeostasis. Dysregulation of the innate …
uropathogenic invasion and maintaining immune homeostasis. Dysregulation of the innate …