Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
In mammals, the white adipocyte is a cell type that is specialized for storage of energy (in the
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
form of triacylglycerols) and for energy mobilization (as fatty acids). White adipocyte …
Altered adipose tissue and adipocyte function in the pathogenesis of metabolic syndrome
Over the past decade, great progress has been made in understanding the complexity of
adipose tissue biology and its role in metabolism. This includes new insights into the …
adipose tissue biology and its role in metabolism. This includes new insights into the …
[HTML][HTML] Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution
AK Sárvári, EL Van Hauwaert, LK Markussen… - Cell metabolism, 2021 - cell.com
Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …
Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce
Q Li, CE Hagberg, H Silva Cascales, S Lang… - Nature medicine, 2021 - nature.com
Obesity is considered an important factor for many chronic diseases, including diabetes,
cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an …
cardiovascular disease and cancer. The expansion of adipose tissue in obesity is due to an …
Spatial map** reveals human adipocyte subpopulations with distinct sensitivities to insulin
The contribution of cellular heterogeneity and architecture to white adipose tissue (WAT)
function is poorly understood. Herein, we combined spatially resolved transcriptional …
function is poorly understood. Herein, we combined spatially resolved transcriptional …
Identification, discrimination and heterogeneity of fibroblasts
Fibroblasts, the principal cell type of connective tissue, secrete extracellular matrix
components during tissue development, homeostasis, repair and disease. Despite this …
components during tissue development, homeostasis, repair and disease. Despite this …
Metabolic adaptation and maladaptation in adipose tissue
Adipose tissue possesses the remarkable capacity to control its size and function in
response to a variety of internal and external cues, such as nutritional status and …
response to a variety of internal and external cues, such as nutritional status and …
Cellular plasticity of the bone marrow niche promotes hematopoietic stem cell regeneration
Hematopoietic stem cells (HSCs) regenerate after myeloablation, a procedure that adversely
disrupts the bone marrow and drives leptin receptor-expressing cells, a key niche …
disrupts the bone marrow and drives leptin receptor-expressing cells, a key niche …
White adipocyte dysfunction and obesity-associated pathologies in humans
CE Hagberg, KL Spalding - Nature Reviews Molecular Cell Biology, 2024 - nature.com
The prevalence of obesity and associated chronic diseases continues to increase
worldwide, negatively impacting on societies and economies. Whereas the association …
worldwide, negatively impacting on societies and economies. Whereas the association …
[HTML][HTML] Mechanisms of insulin resistance related to white, beige, and brown adipocytes
MP Czech - Molecular metabolism, 2020 - Elsevier
Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …