[HTML][HTML] Phase separation and neurodegenerative diseases: a disturbance in the force
A Zbinden, M Pérez-Berlanga, P De Rossi… - Developmental cell, 2020 - cell.com
Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …
Intrinsically disordered proteins and their “mysterious”(meta) physics
VN Uversky - Frontiers in Physics, 2019 - frontiersin.org
Recognition of the natural abundance and functional importance of intrinsically disordered
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
proteins (IDPs), and protein hybrids that contain both intrinsically disordered protein regions …
IUPred2A: context-dependent prediction of protein disorder as a function of redox state and protein binding
The structural states of proteins include ordered globular domains as well as intrinsically
disordered protein regions that exist as highly flexible conformational ensembles in …
disordered protein regions that exist as highly flexible conformational ensembles in …
flDPnn: Accurate intrinsic disorder prediction with putative propensities of disorder functions
Identification of intrinsic disorder in proteins relies in large part on computational predictors,
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
which demands that their accuracy should be high. Since intrinsic disorder carries out a …
Pi-Pi contacts are an overlooked protein feature relevant to phase separation
Protein phase separation is implicated in formation of membraneless organelles, signaling
puncta and the nuclear pore. Multivalent interactions of modular binding domains and their …
puncta and the nuclear pore. Multivalent interactions of modular binding domains and their …
NetSurfP‐2.0: Improved prediction of protein structural features by integrated deep learning
The ability to predict local structural features of a protein from the primary sequence is of
paramount importance for unraveling its function in absence of experimental structural …
paramount importance for unraveling its function in absence of experimental structural …
MobiDB: intrinsically disordered proteins in 2021
The MobiDB database (URL: https://mobidb. org/) provides predictions and annotations for
intrinsically disordered proteins. Here, we report recent developments implemented in …
intrinsically disordered proteins. Here, we report recent developments implemented in …
ELM—the eukaryotic linear motif resource in 2020
M Kumar, M Gouw, S Michael… - Nucleic acids …, 2020 - academic.oup.com
Studies on the DNA-binding properties of transcription factors are important in searching for
the downstream genes regulated by these factors. In the present study, we report on the …
the downstream genes regulated by these factors. In the present study, we report on the …
Analyzing protein disorder with IUPred2A
IUPred2A is a combined prediction tool designed to discover intrinsically disordered or
conditionally disordered proteins and protein regions. Intrinsically disordered regions exist …
conditionally disordered proteins and protein regions. Intrinsically disordered regions exist …
Liquid–liquid phase separation by intrinsically disordered protein regions of viruses: Roles in viral life cycle and control of virus–host interactions
Intrinsically disordered proteins (IDPs) are unable to adopt a unique 3D structure under
physiological conditions and thus exist as highly dynamic conformational ensembles. IDPs …
physiological conditions and thus exist as highly dynamic conformational ensembles. IDPs …