Before menopause, women are protected from atherosclerotic heart disease associated with
obesity relative to men. Sex hormones have been proposed as a mechanism that …

Age, apolipoprotein E ε4 (APOE) and chromosomal sex are well-established risk factors for
late-onset Alzheimer's disease (LOAD; AD). Over 60% of persons with AD harbor at least …

Sexual dimorphism in energy metabolism is now established and suggested to affect many
aspects of metabolic diseases, and-in particular-diabetes, and obesity. This is strongly …

Alzheimer's disease (AD) is the most common form of dementia. Currently, there is no
effective medication for the prevention or treatment of AD. This has led to the search for …

Background Hematologic and biochemical analytes of Sprague-Dawley rats are commonly
used to determine effects that were induced by treatment and to evaluate organ dysfunction …

The objective of the present study was to conduct the first systematic review and meta-
analysis of prospective studies investigating the associations between total cholesterol (TC) …

Despite many diabetic patients having hypercholesterolemia, the association of total
cholesterol (TC) levels with CVD risk in type 2 diabetes (T2D) patients is unclear. Diagnosis …

Genetic variation in apolipoprotein E (APOE) influences Alzheimer's disease (AD) risk.
APOE ε4 alleles are the strongest genetic risk factor for late onset sporadic AD. The AD risk …

Alzheimer's disease (AD) is a chronic brain disorder characterized by cognitive impairment,
cholinergic dysfunction, inflammation, tau and beta-amyloid pathology and vascular …

Nutrition exerts a life-long impact on human health, and the interaction between nutrition
and health has been known for centuries. The recent literature has suggested that nutrition …