Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

Recent transcriptome analyses have revealed that noncoding RNAs (ncRNAs) are broadly
expressed in mammalian cells and abundant in the CNS, with tissue and cell type-specific …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

A transcriptional regulatory nuclear factor kappa B (NF-ΚB) protein is a modulator of cellular
biological activity via binding to a promoter region in the nucleus and transcribing various …

Recently, it has been shown that blocking the binding of valosin-containing protein (VCP) to
mutant huntingtin (mtHtt) can prevent neuronal mitochondrial autophagy in Huntington's …

MicroRNAs (miRNAs) are small, abundant RNA molecules that constitute part of the cell's
non-coding RNA “dark matter.” In recent years, the discovery of miRNAs has revolutionised …

Objective Huntington's disease (HD) is a genetic neurodegenerative disease that is caused
by abnormal CAG expansion. Altered microRNA (miRNA) expression also causes abnormal …

The central nervous system is characterized by a high content of sphingolipids and by a high
diversity in terms of different structures. Stage-and cell-specific sphingolipid metabolism and …

Mutations in fused in sarcoma (FUS) are linked to amyotrophic lateral sclerosis (ALS), a fatal
neurodegenerative disease affecting both upper and lower motor neurons. While it is …

MicroRNAs (miRNAs) are important regulators of several biological processes, such as cell
growth, cell proliferation, embryonic development, tissue differentiation, and apoptosis …