Tamoxifen is a drug commonly used in the treatment of breast cancer, especially for
postmenopausal patients. However, its efficacy is limited by the development of drug …

Lipids, as one of the three primary energy sources, provide energy for all cellular life
activities. Lipids are also known to be involved in the formation of cell membranes and play …

Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …

Simple Summary Cancer is the prime cause of death globally. The altered stimulation of
signaling pathways controlled by human kinases has often been observed in various human …

Sphingosine 1‐phosphate (S1P) is a bioactive lipid that binds to a family of G protein‐
coupled receptors (S1P1–5) and intracellular targets, such as HDAC1/2, that are functional …

Triple-negative breast cancer (TNBC) is a subset of breast cancer with aggressive
characteristics and few therapeutic options. The lack of an appropriate therapeutic target is a …

Cancer is a common and complex disease with high incidence and mortality rates, which
causes a severe public health problem worldwide. As one of the standard therapeutic …

Estrogen receptor α (ERα) functions as a ligand dependent transcription factor that directly
binds specific estrogen responsive elements, thus regulating the transcription of estrogen …

Sphingosine kinase 1 (SphK1) is an oncogenic lipid kinase that catalyzes the formation of
sphingosine-1-phosphate via phosphorylation of sphingosine and known to play a crucial …

Triple-negative breast cancer (TNBC) is very aggressive with high metastatic and mortality
rates and unfortunately, except for chemotherapy, there are few therapeutic options. The …