Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Simple Summary Diffuse gliomas are a type of brain tumour afflicting adults and children,
often with a fatal outcome. An accurate diagnosis is required to give patients correct …

The high efficacy of therapeutic cancer vaccines in preclinical studies has yet to be fully
achieved in clinical trials. Tumor immune suppression is a critical factor that hampers the …

Mutations on the epidermal growth factor receptor (EGFR), induction of angiogenesis, and
reprogramming cellular energetics are all biological features acquired by tumor cells during …

Cancer represents a significant public health problem. More than 18.1 million people are
annually diagnosed with cancer and 9.6 million die mainly due to metastatic disease …

Background Anti-angiogenic therapy in certain cancers has been associated with improved
control of tumor growth and metastasis. Development of anti-angiogenic agents has …

Glioblastoma (GBM) is the most frequent and aggressive type of brain tumor. There are
limited therapeutic options for GBM so that new and effective agents are urgently needed …

Anti-vascular endothelial growth factor (anti-VEGF) therapy applied to solid tumors is a
promising strategy, yet, the challenge to deliver these agents at high drug concentrations …

Cetuximab is the sole anti-EGFR monoclonal antibody that is FDA approved to treat head
and neck squamous cell carcinoma (HNSCC). However, no predictive biomarkers of …

A large number of classic antineoplastic agents are derived from plants. Euphorbia tirucalli
L.(Euphorbiaceae) is a subtropical and tropical plant, used in Brazilian folk medicine against …