Cellular therapies using regulatory T (Treg) cells are currently undergoing clinical trials for
the treatment of autoimmune diseases, transplant rejection and graft-versus-host disease. In …

Autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid
Arthritis (RA) are characterized by the breakdown of immunological tolerance. Defects of …

Autoimmune disease, caused by unwanted immune responses to self-antigens, affects
millions of people each year and poses a great social and economic burden to individuals …

The induction of graft tolerance remains the holy grail of transplantation. This is important as
chronic allograft dysfunction and the side effects of immunosuppression regimens place a …

CD4+ regulatory T cells (Treg) expressing the forkhead box protein 3 (FOXP3) transcription
factor (Tregs) are instrumental for the prevention of autoimmune diseases. There is …

Regulatory T (Treg) cells are a group of CD4+ T cell with high expression of CD25 and cell
linage specific transcription factor forkhead box P3 (Foxp3) and play a vital role in …

Graft-versus-host disease (GVHD) is the leading cause of morbidity and mortality after
allogeneic hematopoietic stem cell transplantation (allo-HSCT). Immunomodulation using …

The primary function of regulatory T cells (Tregs) is blocking the pathogenic immunological
response mediated by autoreactive cells, establishing and maintaining immune …

Therapeutic advances using targeted biologicals and small‐molecule drugs have achieved
significant success in the treatment of chronic allergic, autoimmune, and inflammatory …

Transforming growth factor‐beta (TGF‐β) family proteins mediate many vital biological
functions in growth, development and regulation of the immune system. TGF‐β itself controls …