Over the years, click and bioorthogonal reactions have been the subject of considerable
research efforts. These high-performance chemical reactions have been developed to meet …

Dendritic polymers have highly branched three‐dimensional architectures, the fourth type
apart from linear, cross‐linked, and branched one. They possess not only a large number of …

Bioorthogonal chemistry is a powerful tool to site-specifically activate drugs in living systems.
Bioorthogonal reactions between a pair of biologically reactive groups can rapidly and …

Glycans are involved in numerous biological recognition events. Being secondary gene
products, their labeling by genetic methods–comparable to GFP labeling of proteins–is not …

The use of nanomedicine for cancer treatment takes advantage of its preferential
accumulation in tumors owing to the enhanced permeability and retention (EPR) effect. The …

Traditionally, organic chemical reactions require organic solvents, toxic catalysts, heat, or
high pressure. However, copper‐free click chemistry has been shown to have favorable …

Metabolic glycoengineering with unnatural sugars provides a powerful tool to label cell
membranes with chemical tags for subsequent targeted conjugation of molecular cargos via …

Nanomedicine is extensively employed for cancer treatment owing to its unique advantages
over conventional drugs and imaging agents. This increased attention to nanomedicine …

Albumin has shown remarkable promise as a natural drug carrier by improving
pharmacokinetic (PK) profiles of anticancer drugs for tumor-targeted delivery. The …

Bioorthogonal chemistry reactions occur in physiological conditions without interfering with
normal physiological processes. Through metabolic engineering, bioorthogonal groups can …