GPCRs (G protein-coupled receptors), also known as 7 transmembrane domain receptors,
are the largest receptor family in the human genome, with≈ 800 members. GPCRs regulate …

G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in
a wide range of physiological functions and in a large number of Food and Drug …

Gouty arthritis evokes joint pain and inflammation. Mechanisms driving gout pain and
inflammation remain incompletely understood. Here we show that CXCL5 activates CXCR2 …

Manipulating grain size is an effective strategy for increasing cereal yields. Here we identify
a pathway composed of five subunits of the heterotrimeric G proteins that regulate grain …

The drive toward more sustainable agriculture has raised the profile of crop plant nutrient-
use efficiency. Here we show that a major rice nitrogen-use efficiency quantitative trait locus …

Heterotrimeric G proteins have a crucial role as molecular switches in signal transduction
pathways mediated by G-protein-coupled receptors. Extracellular stimuli activate these …

G protein-coupled receptors (GPCRs) are the largest class of drug targets, largely owing to
their druggability, diversity and physiological efficacy. Many drugs selectively target specific …

▪ Abstract Protein degradation is deployed to modulate the steady-state abundance of
proteins and to switch cellular regulatory circuits from one state to another by abrupt …

In multicellular organisms from Caenorhabditis elegans to Homo sapiens, the maintenance
of homeostasis is dependent on the continual flow and processing of information through a …

G-protein-gated inward rectifier K+ (GIRK) channels allow neurotransmitters, through G-
protein-coupled receptor stimulation, to control cellular electrical excitability. In cardiac and …