Identifying the target cells of a hormone is a key step in understanding its function. Once the
molecular nature of the receptors for a hormone has been established, researchers can use …

Introduction 3. Melatonin receptors 3.1. MT1 and MT2 melatonin receptors 3.1. 1. Molecular
structure 3.1. 2. Pharmacology 3.1. 2.1. Efficacy, potency and affinity 3.1. 2.2. Ligand …

A fall in nocturnal plasma melatonin occurs in patients with cluster headache, suggesting
that melatonin may play a role in the promotion of attacks. During a cluster period, we …

Cardiovascular diseases account for approximately one‐third of all deaths each year. Of
this, hypertension accounts for approximately 9.4 million deaths. Melatonin, the primary …

Most of the anatomical and molecular substrates of the system that encodes changes in
photoperiod in the duration of melatonin secretion, and the receptor molecules that read this …

Melatonin, as a neuroendocrine hormone, is produced primarily by the pineal gland.
Melatonin, a pleotropic molecule, acts as a free radical scavenger, antioxidant, and regulator …

Acuna‐Costroviejo D, Reiter RJ, Menéndez‐Peláez A, Pablos MI, Burgos A.
Characterization of high‐affinity melatonin binding sites in purified cell nuclei of rat liver. J …

The role exerted by melatonin in human physiology has not been completely ascertained.
Melatonin levels have been measured in different physiopathological conditions, but the …

The adult human cerebellum expresses melatonin receptors with high density in the external
zone of the molecular layer. Cloning of the receptor cDNA isolated by RT-PCR from human …

The cyclic recurrence of cluster periods and the regular timing of headache occurrence in
cluster headache (CH) induced us to study the circadian secretion of melatonin and cortisol …