The immunogenetics of multiple sclerosis: A comprehensive review
JA Hollenbach, JR Oksenberg - Journal of autoimmunity, 2015 - Elsevier
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and
common cause of non-traumatic neurological disability in young adults. The likelihood for an …
common cause of non-traumatic neurological disability in young adults. The likelihood for an …
Multiple sclerosis: risk factors, prodromes, and potential causal pathways
Multiple sclerosis (MS) is a common, complex neurological disease. The precise aetiology of
MS is not yet known, although epidemiological data indicate that both genetic and …
MS is not yet known, although epidemiological data indicate that both genetic and …
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
Nature, 2011 - nature.com
Multiple sclerosis is a common disease of the central nervous system in which the interplay
between inflammatory and neurodegenerative processes typically results in intermittent …
between inflammatory and neurodegenerative processes typically results in intermittent …
Class II HLA interactions modulate genetic risk for multiple sclerosis
Nature genetics, 2015 - nature.com
Association studies have greatly refined the understanding of how variation within the
human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the …
human leukocyte antigen (HLA) genes influences risk of multiple sclerosis. However, the …
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis
The human leukocyte antigen (HLA) haplotype DRB1* 15: 01 is the major risk factor for
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
multiple sclerosis (MS). Here, we find that DRB1* 15: 01 is hypomethylated and …
Fine-map** the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects
NA Patsopoulos, LF Barcellos, RQ Hintzen… - PLoS …, 2013 - journals.plos.org
The major histocompatibility complex (MHC) region is strongly associated with multiple
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …
sclerosis (MS) susceptibility. HLA-DRB1* 15: 01 has the strongest effect, and several other …
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
We report the results of a meta-analysis of genome-wide association scans for multiple
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects …
sclerosis (MS) susceptibility that includes 2,624 subjects with MS and 7,220 control subjects …
[HTML][HTML] The neurobiology of multiple sclerosis: genes, inflammation, and neurodegeneration
SL Hauser, JR Oksenberg - Neuron, 2006 - cell.com
The autoimmune model of multiple sclerosis (MS) pathogenesis provided for many years a
useful but incomplete conceptual framework for understanding the complex array of factors …
useful but incomplete conceptual framework for understanding the complex array of factors …
Primary-progressive multiple sclerosis
DH Miller, SM Leary - The Lancet Neurology, 2007 - thelancet.com
Summary About 10–15% of patients with multiple sclerosis (MS) present with gradually
increasing neurological disability, a disorder known as primary-progressive multiple …
increasing neurological disability, a disorder known as primary-progressive multiple …
Mendelian randomization shows a causal effect of low vitamin D on multiple sclerosis risk
Objective: We sought to estimate the causal effect of low serum 25 (OH) D on multiple
sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or …
sclerosis (MS) susceptibility that is not confounded by environmental or lifestyle factors or …