A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

F Anaeigoudari, A Anaeigoudari… - Physiological …, 2023 - Wiley Online Library
Application of herbal medicines in the treatment of diseases is in the center of attention of
medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the …

Gut-derived serotonin and its emerging roles in immune function, inflammation, metabolism and the gut–brain axis

S Banskota, WI Khan - Current Opinion in Endocrinology …, 2022 - journals.lww.com
Emerging evidence regarding the role of peripheral 5-HT in the regulation of various
physiological and pathophysiological conditions opens up new targets for researchers to …

Adverse effect of oxidized cholesterol exposure on colitis is mediated by modulation of gut microbiota

C Yan, SH Huang, HF Ding, E Kwek, JH Liu… - Journal of Hazardous …, 2023 - Elsevier
Both cholesterol and oxidized cholesterol (OXC) are present in human diets. The incidence
of inflammatory bowel diseases (IBDs) is increasing in the world. The present study was to …

Saffron extract (Safr'Inside™) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and gut …

MG Pontifex, E Connell, G Le Gall, L Pourtau… - Food & Function, 2022 - pubs.rsc.org
Treatment of anxiety and depression predominantly centres around pharmacological
interventions, which have faced criticism for their associated side effects, lack of efficacy and …

Phytotherapy of mood disorders in the light of microbiota-gut-brain axis.

M Korczak, M Pilecki, S Granica, A Gorczynska… - Phytomedicine, 2023 - Elsevier
Background Clinical research in natural product-based psychopharmacology has revealed
a variety of promising herbal medicines that may provide benefit in the treatment of mild …

Gut microbiota-derived short-chain fatty acids: novel regulators of intestinal serotonin transporter

B Buey, A Forcén, L Grasa, E Layunta, JE Mesonero… - Life, 2023 - mdpi.com
Serotonin (5-HT) is a key neurotransmitter synthesized both in the gut and the central
nervous system. It exerts its signaling through specific receptors (5-HTR), which regulate …

Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model

G Singh, H Brim, Y Haileselassie, S Varma… - Current Issues in …, 2023 - mdpi.com
Despite the existence of effective drugs used to treat inflammatory bowel disease (IBD),
many patients fail to respond or lose response over time. Further, many drugs can carry …

[HTML][HTML] Saffron as a Promising Therapy for Inflammatory Bowel Disease

M Rashid, R Rashid, S Saroya, M Deverapalli, H Brim… - Nutrients, 2024 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammatory illness of the gastrointestinal
tract (GI), characterized by recurrent episodes of inflammation and tissue destruction. It …

An examination into the mental and physical effects of a saffron extract (affron®) in recreationally-active adults: A randomized, double-blind, placebo-controlled study

AL Lopresti, SJ Smith - Journal of the International Society of Sports …, 2022 - Taylor & Francis
Background Saffron, derived from the stigmas of the Crocus Sativus flower, has been shown
in several studies to improve mood and wellbeing in adults experiencing low mood and …

Saffron, its active components, and their association with DNA and histone modification: A narrative review of current knowledge

M Rashid, H Brim, H Ashktorab - Nutrients, 2022 - mdpi.com
Intensive screening for better and safer medications to treat diseases such as cancer and
inflammatory diseases continue, and some phytochemicals have been discovered to have …