Malignant disease occurs when neoplastic cells abandon their primary site of accretion,
cross tissue boundaries and penetrate the vasculature to colonize distant sites. This process …

Metastasis follows the inappropriate activation of a genetic programme termed invasive
growth, which is a physiological process that occurs during embryonic development and …

Osteosarcoma is the most common nonhematologic malignancy of bone in children and
adults. The peak incidence occurs in the second decade of life, with a smaller peak after age …

In this Update, the cytogenetic and molecular genetic findings in osteosarcoma (OS) and
some related tumors published since our book appeared in 1994 [1] will be presented and …

It has been difficult to identify the molecular features central to the pathogenesis of
osteosarcoma owing to a lack of understanding of the cell or origin, the absence of …

Abstract Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are rare tumors that often
occur in patients with neurofibromatosis 1. Surgical resection represents the mainstay of …

The MET proto-oncogene was first identified in osteosarcoma cells exposed to carcinogens.
Although expressed in many normal cells, MET is overexpressed in many human cancers …

Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions are well established
biological events which have an important role in not just normal tissue and organ …

Osteosarcoma (OS) is an aggressive bone malignancy with a high relapse rate despite
combined treatment with surgery and multiagent chemotherapy. As for other cancers, OS …

The MET oncogene was causally involved in the pathogenesis of a rare tumor, ie, the
papillary renal cell carcinoma, in which activating mutations, either germline or somatic …