[HTML][HTML] Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids

AQ Khan, K Rashid, AA AlAmodi, MV Agha… - Biomedicine & …, 2021 - Elsevier
Reactive oxygen species play crucial role in biological homeostasis and pathogenesis of
human diseases including cancer. In this line, now it has become evident that ROS …

Molecular mechanisms of sanguinarine in cancer prevention and treatment

A Ullah, N Ullah, T Nawaz, T Aziz - Anti-Cancer Agents in …, 2023 - benthamdirect.com
Historically, natural plant-derived drugs received a great impact of consideration in the
treatment of several human-associated disorders. Cancer is a devastating disease and the …

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif… - autophagy, 2021 - Taylor & Francis
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

[HTML][HTML] Guidelines for the use and interpretation of assays for monitoring autophagy 1

DJ Klionsky, AK Abdel-Aziz, S Abdelfatah… - …, 2021 - pmc.ncbi.nlm.nih.gov
In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

[HTML][HTML] Targeting hypoxia-inducible factor-1alpha: A new strategy for triple-negative breast cancer therapy

Q Liu, C Guan, C Liu, H Li, J Wu, C Sun - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Triple-negative breast cancer (TNBC) is a subtype of breast cancer that is highly aggressive
and hypoxic compared with other subtypes. The role of hypoxia inducible factor 1α (HIF-1α) …

[HTML][HTML] Bioactivity and mechanism of action of sanguinarine and its derivatives in the past 10 years

LJ Huang, JX Lan, JH Wang, H Huang, K Lu… - Biomedicine & …, 2024 - Elsevier
Sanguinarine is a quaternary ammonium benzophenanthine alkaloid found in traditional
herbs such as Chelidonium, Corydalis, Sanguinarum, and Borovula. It has been proven to …

Intein-mediated temperature control for complete biosynthesis of sanguinarine and its halogenated derivatives in yeast

Y Gou, D Li, M Zhao, M Li, J Zhang, Y Zhou… - Nature …, 2024 - nature.com
While sanguinarine has gained recognition for antimicrobial and antineoplastic activities, its
complex conjugated structure and low abundance in plants impede broad applications …

Designing strategies, structural activity relationship and biological activity of recently developed nitrogen containing heterocyclic compounds as epidermal growth …

R Pal, G Teli, GSP Matada, PS Dhiwar - Journal of Molecular Structure, 2023 - Elsevier
Cancer cells have the ability of dysregulation and autonomous proliferation due to
unchecked production of definite molecules. These molecules are involved in the cell growth …

Sanguinarine ameliorates DSS induced ulcerative colitis by inhibiting NLRP3 inflammasome activation and modulating intestinal microbiota in C57BL/6 mice

X Li, X Wu, Q Wang, W Xu, Q Zhao, N Xu, X Hu, Z Ye… - Phytomedicine, 2022 - Elsevier
Background Sanguinarine (SAN) is an important natural anti-inflammatory constitutes and
dietary supplementation with SAN could improve the relative length of the intestine, alter gut …

Targeting oxeiptosis-mediated tumor suppression: a novel approach to treat colorectal cancers by sanguinarine

S Pallichankandy, F Thayyullathil, AR Cheratta… - Cell Death …, 2023 - nature.com
Oxeiptosis is a recently identified reactive oxygen species (ROS)-sensitive, caspase
independent, non-inflammatory regulated cell death pathway. The activation of Kelch-like …