Progress has been made in our understanding of the mechanisms of endoplasmic reticulum
(ER) proteostasis, ER stress and the unfolded protein response (UPR), as well as ER stress …

Acute kidney injury (AKI) is a global public health concern associated with high morbidity,
mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably …

The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin
resistance and associated with several sequelae of metabolic syndrome in humans …

Endoplasmic reticulum stress is an evolutionarily conserved cell stress response associated
with numerous diseases, including cardiac hypertrophy and heart failure. The major …

Neurodegenerative disorders, such as Parkinson's disease (PD), Alzheimer's disease (AD),
Amyotrophic lateral sclerosis (ALS), and Huntington's disease (HD), are the most concerning …

Macrophages are central to the pathogenesis of kidney disease and serve as an effective
therapeutic target for kidney injury and fibrosis. Among them, M2-type macrophages have …

Acute kidney injury (AKI) is a medical condition characterized by kidney damage with a rapid
decline of renal function, which is associated with high mortality and morbidity. Recent …

Cells use an exquisite network of mechanisms to maintain the integrity and functionality of
their protein components. In the endoplasmic reticulum (ER), these networks of protein …

Background Acute kidney injury (AKI) may lead to the development of chronic kidney
disease (CKD), ie AKI-CKD transition, but the underlying mechanism remains largely …

Acute kidney injury (AKI) is a frequent complication of hospitalization and is associated with
an increased risk of chronic kidney disease (CKD), end-stage renal disease (ESRD), and …