Extracellular vesicles in immunomodulation and tumor progression
Extracellular vesicles have emerged as prominent regulators of the immune response
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …
during tumor progression. EVs contain a diverse repertoire of molecular cargo that plays a …
Immunotherapy for osteosarcoma: Fundamental mechanism, rationale, and recent breakthroughs
C Chen, L **e, T Ren, Y Huang, J Xu, W Guo - Cancer letters, 2021 - Elsevier
Osteosarcoma (OS) is the most common primary malignancy of the bone and has a high
propensity for local invasion and metastasis. Although combining surgery with …
propensity for local invasion and metastasis. Although combining surgery with …
Role of exosomal non-coding RNAs from tumor cells and tumor-associated macrophages in the tumor microenvironment
Z Xu, Y Chen, L Ma, Y Chen, J Liu, Y Guo, T Yu… - Molecular Therapy, 2022 - cell.com
Exosomes have a crucial role in intercellular communication and mediate interactions
between tumor cells and tumor-associated macrophages (TAMs). Exosome-encapsulated …
between tumor cells and tumor-associated macrophages (TAMs). Exosome-encapsulated …
Lin28B-high breast cancer cells promote immune suppression in the lung pre-metastatic niche via exosomes and support cancer progression
M Qi, Y **a, Y Wu, Z Zhang, X Wang, L Lu, C Dai… - Nature …, 2022 - nature.com
The formation of pre-metastatic niche is a key step in the metastatic burden. The pluripotent
factor Lin28B is frequently expressed in breast tumors and is particularly upregulated in the …
factor Lin28B is frequently expressed in breast tumors and is particularly upregulated in the …
Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …
Extracellular vesicles in cancer—implications for future improvements in cancer care
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …
cell–cell communication within complex tissue environments. Such communication …
Effect of exosomal miRNA on cancer biology and clinical applications
Z Sun, K Shi, S Yang, J Liu, Q Zhou, G Wang, J Song… - Molecular cancer, 2018 - Springer
Exosomes, extracellular vesicles with diameters ranging from 30 to 150 nm, are widely
present in various body fluids. Recently, microRNAs (miRNAs) have been identified in …
present in various body fluids. Recently, microRNAs (miRNAs) have been identified in …
Extracellular vesicle heterogeneity: subpopulations, isolation techniques, and diverse functions in cancer progression
Cells release membrane enclosed nano-sized vesicles termed extracellular vesicles (EVs)
that function as mediators of intercellular communication by transferring biological …
that function as mediators of intercellular communication by transferring biological …
Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy
Y Ding, Y Wang, Q Hu - Exploration, 2022 - Wiley Online Library
Immunotherapy strategies that use cell‐based delivery systems have sparked much interest
in the treatment of malignancies, owing to their high biocompatibility, excellent tumor …
in the treatment of malignancies, owing to their high biocompatibility, excellent tumor …
Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …