Stem cell therapy in heart diseases–cell types, mechanisms and improvement strategies
P Müller, H Lemcke, R David - Cellular Physiology and Biochemistry, 2018 - karger.com
A large number of clinical trials have shown stem cell therapy to be a promising therapeutic
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
approach for the treatment of cardiovascular diseases. Since the first transplantation into …
Inflammation and biomaterials: role of the immune response in bone regeneration by inorganic scaffolds
The regulatory role of the immune system in maintaining bone homeostasis and restoring its
functionality, when disturbed due to trauma or injury, has become evident in recent years …
functionality, when disturbed due to trauma or injury, has become evident in recent years …
Amelioration of post-traumatic osteoarthritis via nanoparticle depots delivering small interfering RNA to damaged cartilage
The progression of osteoarthritis is associated with inflammation triggered by the enzymatic
degradation of extracellular matrix in injured cartilage. Here we show that a locally injected …
degradation of extracellular matrix in injured cartilage. Here we show that a locally injected …
Screening and validation of lncRNAs and circRNAs as miRNA sponges
Intensive research in past two decades has uncovered the presence and importance of
noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs …
noncoding RNAs (ncRNAs), which includes microRNAs (miRs) and long ncRNAs …
miRNA therapeutics: a new class of drugs with potential therapeutic applications in the heart
miRNAs are small non-coding RNAs (ncRNAs), which regulate gene expression. Here, the
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …
authors describe the contribution of miRNAs to cardiac biology and disease. They discuss …
Roles of noncoding RNA in reproduction
C He, K Wang, Y Gao, C Wang, L Li, Y Liao, K Hu… - Frontiers in …, 2021 - frontiersin.org
The World Health Organization predicts that infertility will be the third major health threat
after cancer and cardiovascular disease, and will become a hot topic in medical research …
after cancer and cardiovascular disease, and will become a hot topic in medical research …
MicroRNAs as modulators of oral tumorigenesis—A focused review
Oral cancers constitute the majority of head and neck tumors, with a relatively high incidence
and poor survival rate in develo** countries. While the five-year survival rates of the oral …
and poor survival rate in develo** countries. While the five-year survival rates of the oral …
Delivering nucleic‐acid based nanomedicines on biomaterial scaffolds for orthopedic tissue repair: Challenges, progress and future perspectives
As well as acting to fill defects and allow for cell infiltration and proliferation in regenerative
medicine, biomaterial scaffolds can also act as carriers for therapeutics, further enhancing …
medicine, biomaterial scaffolds can also act as carriers for therapeutics, further enhancing …
Next generation bone tissue engineering: non-viral miR-133a inhibition using collagen-nanohydroxyapatite scaffolds rapidly enhances osteogenesis
Bone grafts are the second most transplanted materials worldwide at a global cost to
healthcare systems valued over $30 billion every year. The influence of microRNAs in the …
healthcare systems valued over $30 billion every year. The influence of microRNAs in the …
Technologies for controlled, local delivery of siRNA
The discovery of RNAi in the late 1990s unlocked a new realm of therapeutic possibilities by
enabling potent and specific silencing of theoretically any desired genetic target. Better …
enabling potent and specific silencing of theoretically any desired genetic target. Better …