[HTML][HTML] Bone grafts and biomaterials substitutes for bone defect repair: A review

W Wang, KWK Yeung - Bioactive materials, 2017 - Elsevier
Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

[HTML][HTML] Bone physiological microenvironment and healing mechanism: Basis for future bone-tissue engineering scaffolds

G Zhu, T Zhang, M Chen, K Yao, X Huang, B Zhang… - Bioactive materials, 2021 - Elsevier
Bone-tissue defects affect millions of people worldwide. Despite being common treatment
approaches, autologous and allogeneic bone grafting have not achieved the ideal …

Alloying design of biodegradable zinc as promising bone implants for load-bearing applications

H Yang, B Jia, Z Zhang, X Qu, G Li, W Lin, D Zhu… - Nature …, 2020 - nature.com
Magnesium-based biodegradable metals (BMs) as bone implants have better mechanical
properties than biodegradable polymers, yet their strength is roughly less than 350 MPa. In …

Design of biodegradable, implantable devices towards clinical translation

C Li, C Guo, V Fitzpatrick, A Ibrahim… - Nature Reviews …, 2020 - nature.com
Biodegradable materials, including natural and synthetic polymers and hydrolyzable metals,
constitute the main components of temporary, implantable medical devices. Besides the …

Glucagon-like peptide-1 receptor: mechanisms and advances in therapy

Z Zheng, Y Zong, Y Ma, Y Tian, Y Pang… - … and Targeted Therapy, 2024 - nature.com
Abstract The glucagon-like peptide-1 (GLP-1) receptor, known as GLP-1R, is a vital
component of the G protein-coupled receptor (GPCR) family and is found primarily on the …

Biodegradable magnesium‐based implants in orthopedics—a general review and perspectives

JL Wang, JK Xu, C Hopkins, DHK Chow… - Advanced …, 2020 - Wiley Online Library
Biodegradable Mg‐based metals may be promising orthopedic implants for treating
challenging bone diseases, attributed to their desirable mechanical and osteopromotive …

Current status on clinical applications of magnesium-based orthopaedic implants: A review from clinical translational perspective

D Zhao, F Witte, F Lu, J Wang, J Li, L Qin - Biomaterials, 2017 - Elsevier
As a new generation of medical metallic material, magnesium (Mg) and its alloys with or
without surface coating have attracted a great deal of attention due to its biodegradability …

Bone biomaterials and interactions with stem cells

C Gao, S Peng, P Feng, C Shuai - Bone research, 2017 - nature.com
Bone biomaterials play a vital role in bone repair by providing the necessary substrate for
cell adhesion, proliferation, and differentiation and by modulating cell activity and function. In …

[HTML][HTML] Magnesium-based biomaterials as emerging agents for bone repair and regeneration: From mechanism to application

H Zhou, B Liang, H Jiang, Z Deng, K Yu - Journal of Magnesium and Alloys, 2021 - Elsevier
Magnesium (Mg) is the fourth most abundant element in the human body and is important in
terms of specific osteogenesis functions. Here, we provide a comprehensive review of the …

[HTML][HTML] Mg bone implant: Features, developments and perspectives

Y Yang, C He, E Dianyu, W Yang, F Qi, D **e, L Shen… - Materials & Design, 2020 - Elsevier
Mg and its alloys have been identified as promising bone implant materials owing to their
natural degradability, good biocompatibility and favorable mechanical properties …