Enabling personalized cancer medicine through analysis of gene-expression patterns
LJ Van't Veer, R Bernards - Nature, 2008 - nature.com
Therapies for patients with cancer have changed gradually over the past decade, moving
away from the administration of broadly acting cytotoxic drugs towards the use of more …
away from the administration of broadly acting cytotoxic drugs towards the use of more …
The emerging role of progesterone receptor membrane component 1 (PGRMC1) in cancer biology
MA Cahill, JA Jazayeri, SM Catalano… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Progesterone receptor membrane component 1 (PGRMC1) is a multi-functional protein with
a heme-binding moiety related to that of cytochrome b 5, which is a putative progesterone …
a heme-binding moiety related to that of cytochrome b 5, which is a putative progesterone …
High-dimensional sparse factor modeling: applications in gene expression genomics
We describe studies in molecular profiling and biological pathway analysis that use sparse
latent factor and regression models for microarray gene expression data. We discuss breast …
latent factor and regression models for microarray gene expression data. We discuss breast …
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers
Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell
cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression …
cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression …
EMT is the dominant program in human colon cancer
A Loboda, MV Nebozhyn, JW Watters, CA Buser… - BMC medical …, 2011 - Springer
Background Colon cancer has been classically described by clinicopathologic features that
permit the prediction of outcome only after surgical resection and staging. Methods We …
permit the prediction of outcome only after surgical resection and staging. Methods We …
Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1–NRF2 pathway, and not the …
AK MacLeod, M McMahon, SM Plummer… - …, 2009 - academic.oup.com
To better understand the role of transcription factor NF-E2-related factor (NRF) 2 in the
human and its contribution to cancer chemoprevention, we have knocked down its negative …
human and its contribution to cancer chemoprevention, we have knocked down its negative …
The predictive value of the 70-gene signature for adjuvant chemotherapy in early breast cancer
M Knauer, S Mook, EJT Rutgers, RA Bender… - Breast cancer research …, 2010 - Springer
Multigene assays have been developed and validated to determine the prognosis of breast
cancer. In this study, we assessed the additional predictive value of the 70-gene …
cancer. In this study, we assessed the additional predictive value of the 70-gene …
Shotgun Stochastic Search for “Large p” Regression
Model search in regression with very large numbers of candidate predictors raises
challenges for both model specification and computation, for which standard approaches …
challenges for both model specification and computation, for which standard approaches …
Identification of candidate molecular markers predicting sensitivity in solid tumors to dasatinib: rationale for patient selection
F Huang, K Reeves, X Han, C Fairchild, S Platero… - Cancer research, 2007 - AACR
Dasatinib is a multitargeted kinase inhibitor that was recently approved for the treatment of
chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic …
chronic myelogenous leukemia and Philadelphia chromosome–positive acute lymphoblastic …
Identification of markers of taxane sensitivity using proteomic and genomic analyses of breast tumors from patients receiving neoadjuvant paclitaxel and radiation
Purpose: To identify molecular markers of pathologic response to neoadjuvant
paclitaxel/radiation treatment, protein and gene expression profiling were done on …
paclitaxel/radiation treatment, protein and gene expression profiling were done on …