The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

TP53 is the most commonly mutated gene in human cancer with over 100,000 literature
citations in PubMed. This is a heavily studied pathway in cancer biology and oncology with a …

Patterns of transcriptional activity are encoded in our genome through regulatory elements
such as promoters or enhancers that, paradoxically, contain similar assortments of …

The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …

Head and neck squamous cell carcinomas (HNSCCs) are an aggressive, genetically
complex and difficult to treat group of cancers. In lieu of truly effective targeted therapies …

Simple Summary The transcription factor p53 is a crucial tumor suppressor that regulates
diverse cellular responses to protect against cancer development. Deactivating p53 …

Despite significant advances in cancer therapy over the years, its complex pathological
process still represents a major health challenge when seeking effective treatment and …

Hepatocellular carcinoma (HCC) is the most frequent liver cancer with high lethality and low
five-year survival rates leading to a substantial worldwide burden for healthcare systems …

Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …

Abstract Development of candidate cancer treatments is a resource-intensive process, with
the research community continuing to investigate options beyond static genomic …