Pioneer factors as master regulators of the epigenome and cell fate
A Balsalobre, J Drouin - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …
The kaleidoscope of microglial phenotypes
ML Dubbelaar, L Kracht, BJL Eggen… - Frontiers in …, 2018 - frontiersin.org
Gene expression analyses of microglia, the tissue-resident macrophages of the central
nervous system (CNS), led to the identification of homeostatic as well as neurological …
nervous system (CNS), led to the identification of homeostatic as well as neurological …
Dissecting immune circuits by linking CRISPR-pooled screens with single-cell RNA-seq
In multicellular organisms, dedicated regulatory circuits control cell type diversity and
responses. The crosstalk and redundancies within these circuits and substantial cellular …
responses. The crosstalk and redundancies within these circuits and substantial cellular …
Expression of the transcription factor PU. 1 induces the generation of microglia-like cells in human cortical organoids
B Cakir, Y Tanaka, FR Kiral, Y ** macrophage identity and their effect on tissue homeostasis
Macrophages provide a critical systemic network cells of the innate immune system.
Emerging data suggest that in addition, they have important tissue-specific functions that …
Emerging data suggest that in addition, they have important tissue-specific functions that …
Direct conversion of fibroblasts to functional neurons by defined factors
Cellular differentiation and lineage commitment are considered to be robust and irreversible
processes during development. Recent work has shown that mouse and human fibroblasts …
processes during development. Recent work has shown that mouse and human fibroblasts …
Direct lineage reprogramming: strategies, mechanisms, and applications
J Xu, Y Du, H Deng - Cell stem cell, 2015 - cell.com
The direct lineage reprogramming of one specialized cell type into another using defined
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …
factors has fundamentally re-shaped traditional concepts regarding the epigenetic stability of …