Molecular and immune landscape of hepatocellular carcinoma to guide therapeutic decision making

R Dhanasekaran, H Suzuki, L Lemaitre, N Kubota… - Hepatology, 2023 - journals.lww.com
Liver cancer, primarily hepatocellular carcinoma (HCC), exhibits highly heterogeneous
histological and molecular aberrations across tumors and within individual tumor nodules …

[HTML][HTML] Liquid biopsy: New opportunities for precision medicine in hepatocellular carcinoma care

IMC Aquino, D Pascut - Annals of Hepatology, 2024 - Elsevier
Liquid biopsy, specifically the analysis of circulating tumor DNA (ctDNA), offers a non-
invasive approach for hepatocellular carcinoma (HCC) diagnosis and management …

Clinical application of circulating tumor DNA in metastatic cancers

N Raei, R Safaralizadeh… - Expert Review of Molecular …, 2023 - Taylor & Francis
Introduction Advances in genomics have facilitated the application of cell-free DNA (cfDNA)
and circulating tumor DNA (ctDNA) in phase II and phase III clinical trials. The various …

Personalized MRD Assessment in Perisurgical ctDNA for Prognostic Prediction in Hepatocellular Carcinoma

J Hu, H Tang, CC Jia, XY Zhang, Y Xu… - Clinical Cancer …, 2024 - aacrjournals.org
Purpose: Detecting residual disease is a critical clinical requirement in the perisurgical
management of patients with resectable hepatocellular carcinoma (HCC). Previous studies …

Diagnostic accuracy of ESR1 mutation detection by cell-free DNA in breast cancer: a systematic review and meta-analysis of diagnostic test accuracy

M Raei, K Heydari, M Tabarestani, A Razavi… - BMC cancer, 2024 - Springer
Background Estrogen receptors express in nearly 70% of breast cancers (ER-positive).
Estrogen receptor alpha plays a fundamental role as a significant factor in breast cancer …

Prospects of liquid biopsy in the prognosis and clinical management of gastrointestinal cancers

D Mondal, S Shinde, V Sinha, V Dixit, S Paul… - Frontiers in Molecular …, 2024 - frontiersin.org
Gastrointestinal (GI) cancers account for one-fourth of the global cancer incidence and are
incriminated to cause one-third of cancer-related deaths. GI cancer includes esophageal …

Dissecting intratumor heterogeneity in HCC: new research strategies and clinical implications

S Behrens, XW Wang - Carcinogenesis, 2022 - academic.oup.com
Hepatocellular carcinoma (HCC) accounts for the majority of liver cancers and is driven by a
multitude of viral, metabolic, and lifestyle factors initiating liver injury that subsequently …

Targeted Molecular Profiling of Circulating Cell-Free DNA in Patients With Advanced Hepatocellular Carcinoma

D Cowzer, JB White, JF Chou, PJ Chen… - JCO Precision …, 2023 - ascopubs.org
PURPOSE Next-generation sequencing (NGS) of tumor-derived, circulating cell-free DNA
(cfDNA) may aid in diagnosis, prognostication, and treatment of patients with hepatocellular …

Developments and current status of cell‐free DNA in the early detection and management of hepatocellular carcinoma

S Du, K Cao, Y Yan, Y Wang, Z Wang… - Journal of …, 2024 - Wiley Online Library
Nowadays, hepatocellular carcinoma (HCC) is still a major threat to human health globally,
with a disappointing prognosis. Regular monitoring of patients at high risk, utilizing …

Current updates on the molecular and genetic signals as diagnostic and therapeutic targets for hepatitis B virus-associated hepatic malignancy

A Adugna, Y Muche, A Melkamu, M Jemal, H Belew… - Heliyon, 2024 - cell.com
Liver cancer caused by the hepatitis B virus (HBV) is the third most common cancer-related
cause of death worldwide. Early detection of HBV-caused hepatic tumors increases the …