Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

Lysine-specific demethylase 5A (KDM5A, also named RBP2 or JARID1A) is a demethylase
that can remove methyl groups from histones H3K4me1/2/3. It is aberrantly expressed in …

Non-small cell lung cancers (NSCLCs) harboring KEAP1 mutations are often resistant to
immunotherapy. Here, we show that KEAP1 targets EMSY for ubiquitin-mediated …

NuRD (nucleosome remodeling and histone deacetylase) is a versatile multi-protein
complex with roles in transcription regulation and the DNA damage response. Here, we …

Histone methylation, one of the most common histone modifications, has fundamental roles
in regulating chromatin-based processes. Jumonji histone lysine demethylases (JMJC …

JARID1 proteins are histone demethylases that both regulate normal cell fates during
development and contribute to the epigenetic plasticity that underlies malignant …

Background Peanut allergy (PA) is a complex disease with both environmental and genetic
risk factors. Previously, PA loci were identified in filaggrin (FLG) and HLA in candidate gene …

Mammalian histone demethylases of the KDM5 family are mediators of gene expression
dynamics during developmental, cellular differentiation, and other nuclear processes. They …

One bottleneck in understanding the principles of 3D chromatin structures is caused by the
paucity of known regulators. Cohesin is essential for 3D chromatin organization, and its …

Background KDM5 family proteins are multi-domain regulators of transcription that when
dysregulated contribute to cancer and intellectual disability. KDM5 proteins can regulate …