[HTML][HTML] Investigating the Interplay between Cardiovascular and Neurodegenerative Disease

JP Cousineau, AM Dawe, M Alpaugh - Biology, 2024 - mdpi.com
Simple Summary Traditionally, models of neurodegenerative diseases focus on changes
within the central nervous system. However, growing evidence indicates there are prominent …

Pharmaceutical and pharmacological studies of Shen Ma Yi Zhi granule for prevention of vascular dementia: A review

S Chang, J Liu, H Li, M Liu, D Shi, L Zhou - Frontiers in Neuroscience, 2022 - frontiersin.org
Background: With dementia significantly increasing hospitalization and disability rates,
worldwide aging of the population presents major challenges to public health. The majority …

ML218 modulates calcium binding protein, oxidative stress, and inflammation during ischemia-reperfusion brain injury in mice

P Sharma, B Sharma, S Ghildiyal… - European Journal of …, 2024 - Elsevier
Cerebral ischemia disrupts calcium homeostasis in the brain causing excitotoxicity, oxidative
stress, inflammation, and neuronal cell apoptosis. During ischemic conditions, T-type …

Selective inhibition of T-type calcium channel preserves ischemic pre-conditioning mediated neuroprotection during cerebral ischemia reperfusion injury in diabetic …

P Sharma, B Sharma, H Kharkwal, S Ghildiyal… - Metabolic Brain …, 2025 - Springer
Ischemic preconditioning (IPC) provides ischemic tolerance and neuroprotection during
cerebral ischemia reperfusion (CI/R) injury. Diabetes abolishes the beneficial effects of …

Calcium Channels as a Potential Therapeutic Target for Alzheimer's Disease

P Sharma, P Thapak, B Chandwani, H Kharkwal… - … Drug Targets for …, 2023 - Springer
Alzheimer's disease (AD) is the most common type of dementia that characterizes the
accumulation of amyloid-β plaques and neurofibrillary tangles in the brain. AD is the most …

Decreased blood pressure with acute administration of quercetin in L‐NAME‐induced hypertensive rats

SA Mkhize, RA Nthlane, SP Xhakaza… - Basic & Clinical …, 2025 - Wiley Online Library
Quercetin is known to reduce blood pressure (BP); however, its acute effects are unclear.
We investigated the acute effects of quercetin on BP, aortic mechanical properties and …

Montelukast Ameliorates 2K1C-Hypertension Induced Endothelial Dysfunction and Associated Vascular Dementia

S Gupta, P Singh, B Sharma - Current Hypertension Reviews, 2024 - ingentaconnect.com
Background: Declined kidney function associated with hypertension is a danger for cognitive
deficits, dementia, and brain injury. Cognitive decline and vascular dementia (VaD) are …

Flutamide alters markers of inflammation and oxidative stress in experimental model of autism

R Mirza, P Sharma, GT Kulkarni… - Research Journal of …, 2023 - indianjournals.com
Autism spectrum disorder (ASD) is a neurodevelopmental disorder withcomplex etiology
and phenotypes. Many clinical and pre-clinical study have demonstrated the association of …

Progesterone attenuate autism-like-phenotype through modulation of cerebral inflammation and oxidative stress

R Mirza, P Sharma, GT Kulkarni, B Sharma - Indian Journal of Physiology …, 2024 - ijpp.com
Objectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that
characterises repetitive behaviour and impairment in social communication as well as …

Mechanisms underlying the therapeutic effects of banxiaxiexin decoction in treating vascular dementia based on network pharmacology and molecular docking

S Liang, L Liu, X Liu, Y Zhang - 2023 - researchsquare.com
Background The Banxiaxiexin decoction constitutes a prevalent Traditional Chinese
Medicine (TCM) formulation employed for the therapeutic intervention of vascular dementia …