Bestrophin-1 is an integral membrane protein, encoded by the BEST1 gene, which is
located in the basolateral membrane of the retinal pigment epithelium. The bestrophin-1 …

Purpose: To review the pathophysiologic principles underlying increased autofluorescence
from the outer retina and subretinal space using selected diseases as examples. Methods …

Recent studies have implicated local inflammation and activation of complement amongst
the processes involved in the pathogenesis of age-related macular degeneration (AMD) …

A2-PE is a pigment that forms as a byproduct of the visual cycle, its synthesis from all-trans-
retinal and phosphatidylethanolamine occurring in photoreceptor outer segments. A2-PE is …

The presence of the regenerable visual pigment rhodopsin has been shown to be primarily
responsible for the acute photo‐damage to the retina. The photoexcitation of rhodopsin …

Accumulation of vitamin A-derived lipofuscin fluorophores in the retinal pigment epithelium
(RPE) is a pathologic feature of recessive Stargardt macular dystrophy, a blinding disease …

The retinal pigment epithelium (RPE) is a monolayer of highly pigmented cells lining the
inner aspect of Bruch's membrane. This pigmentation is due to eumelanin and a possible …

Fluorescent bisretinoids, such as A2E and all-trans-retinal dimer, form as a by-product of
vitamin A cycling in retina and accumulate in retinal pigment epithelial (RPE) cells as …

Every 5 years or so new technologies, or new combinations of old ones, seemingly burst
onto the science scene and are then sought after until they reach the point of becoming …

PURPOSE: To investigate and integrate the photographic, angiographic, and tomographic
findings from a group of patients with various stages of vitelliform macular dystrophy type 2 …