Immune-related adverse events of checkpoint inhibitors
M Ramos-Casals, JR Brahmer, MK Callahan… - Nature reviews Disease …, 2020 - nature.com
Cancer immunotherapies have changed the landscape of cancer treatment during the past
few decades. Among them, immune checkpoint inhibitors, which target PD-1, PD-L1 and …
few decades. Among them, immune checkpoint inhibitors, which target PD-1, PD-L1 and …
NK cells and cancer: you can teach innate cells new tricks
Natural killer (NK) cells are the prototype innate lymphoid cells endowed with potent cytolytic
function that provide host defence against microbial infection and tumours. Here, we review …
function that provide host defence against microbial infection and tumours. Here, we review …
Endocrine toxicity of cancer immunotherapy targeting immune checkpoints
Immune checkpoints are small molecules expressed by immune cells that play critical roles
in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T …
in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T …
NK cell-based immune checkpoint inhibition
Immunotherapy, with an increasing number of therapeutic dimensions, is becoming an
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
important mode of treatment for cancer patients. The inhibition of immune checkpoints …
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance
Clinically acquired resistance to MAPK inhibitor (MAPKi) therapies for melanoma cannot be
fully explained by genomic mechanisms and may be accompanied by co-evolution of intra …
fully explained by genomic mechanisms and may be accompanied by co-evolution of intra …
The emergence of natural killer cells as a major target in cancer immunotherapy
F Souza-Fonseca-Guimaraes, J Cursons… - Trends in …, 2019 - cell.com
Immune 'checkpoint'inhibitors can increase the activity of tumor-resident cytotoxic
lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory …
lymphocytes and have revolutionized cancer treatment. Current therapies block inhibitory …
Soluble immune checkpoints in cancer: production, function and biological significance
D Gu, X Ao, Y Yang, Z Chen, X Xu - Journal for immunotherapy of cancer, 2018 - Springer
Immune checkpoints play important roles in immune regulation, and blocking immune
checkpoints on the cell membrane is a promising strategy in the treatment of cancer. Based …
checkpoints on the cell membrane is a promising strategy in the treatment of cancer. Based …
Clinical experience with CTLA-4 blockade for cancer immunotherapy: From the monospecific monoclonal antibody ipilimumab to probodies and bispecific molecules …
The immune checkpoint cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is an
inhibitory regulator of T-cell mediated responses that has been investigated as target of …
inhibitory regulator of T-cell mediated responses that has been investigated as target of …
Immunotherapy and hypophysitis: clinical presentation, treatment, and biologic insights
A Faje - Pituitary, 2016 - Springer
Introduction Advances in immunotherapy have transformed the management of metastatic
melanoma and generated encouraging results in the treatment of other malignancies …
melanoma and generated encouraging results in the treatment of other malignancies …
Beyond T-cells: functional characterization of CTLA-4 expression in immune and non-immune cell types
D Oyewole-Said, V Konduri, J Vazquez-Perez… - Frontiers in …, 2020 - frontiersin.org
The immune response consists of a finely-tuned program, the activation of which must be
coupled with inhibitory mechanisms whenever initiated. This ensures tight control of …
coupled with inhibitory mechanisms whenever initiated. This ensures tight control of …