HFIP in organic synthesis

HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …

Toolbox for distal C–H bond functionalizations in organic molecules

SK Sinha, S Guin, S Maiti, JP Biswas, S Porey… - Chemical …, 2021 - ACS Publications
Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

Achieving site-selectivity for C–H activation processes based on distance and geometry: a carpenter's approach

G Meng, NYS Lam, EL Lucas… - Journal of the …, 2020 - ACS Publications
The ability to differentiate between highly similar C–H bonds in a given molecule remains a
fundamental challenge in organic chemistry. In particular, the lack of sufficient steric and …

Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions

S Rej, A Das, N Chatani - Coordination Chemistry Reviews, 2021 - Elsevier
In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …

Accessing Remote meta‐ and para‐C(sp2)−H Bonds with Covalently Attached Directing Groups

A Dey, SK Sinha, TK Achar… - Angewandte Chemie …, 2019 - Wiley Online Library
Directing group assisted ortho‐C− H activation has been known for the last few decades. In
contrast, extending the same approach to achieve activation of the distal meta‐and para‐C …

Recent development in transition metal-catalysed C–H olefination

W Ali, G Prakash, D Maiti - Chemical Science, 2021 - pubs.rsc.org
Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds
represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of …

The crucial role of silver (i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability

RL de Carvalho, EBT Diogo, SL Homölle… - Chemical Society …, 2023 - pubs.rsc.org
Transition-metal catalyzed C–H activation reactions have been proven to be useful
methodologies for the assembly of synthetically meaningful molecules. This approach bears …

Pd-catalyzed regioselective activation of C (sp 2)–H and C (sp 3)–H bonds

W Ali, GA Oliver, DB Werz, D Maiti - Chemical Society Reviews, 2024 - pubs.rsc.org
Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

Decoding directing groups and their pivotal role in C− H activation

K Murali, LA Machado, RL Carvalho… - … A European Journal, 2021 - Wiley Online Library
Synthetic organic chemistry has witnessed a plethora of functionalization and
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …

Dual Ligand Enabled Nondirected C–H Chalcogenation of Arenes and Heteroarenes

SK Sinha, S Panja, J Grover, PS Hazra… - Journal of the …, 2022 - ACS Publications
Chalcogenide motifs are present as principal moieties in a vast array of natural products and
complex molecules. Till date, the construction of these chalcogen motifs has been restricted …