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HFIP in organic synthesis
HF Motiwala, AM Armaly, JG Cacioppo… - Chemical …, 2022 - ACS Publications
1, 1, 1, 3, 3, 3-Hexafluoroisopropanol (HFIP) is a polar, strongly hydrogen bond-donating
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …
solvent that has found numerous uses in organic synthesis due to its ability to stabilize ionic …
Toolbox for distal C–H bond functionalizations in organic molecules
Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …
Achieving site-selectivity for C–H activation processes based on distance and geometry: a carpenter's approach
The ability to differentiate between highly similar C–H bonds in a given molecule remains a
fundamental challenge in organic chemistry. In particular, the lack of sufficient steric and …
fundamental challenge in organic chemistry. In particular, the lack of sufficient steric and …
Strategic evolution in transition metal-catalyzed directed C–H bond activation and future directions
In the field of C–H bond functionalization chemistry, directed C–H bond activation strategies
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …
are highly appreciated due to the high efficiency and selectivity of such reactions towards a …
Accessing Remote meta‐ and para‐C(sp2)−H Bonds with Covalently Attached Directing Groups
Directing group assisted ortho‐C− H activation has been known for the last few decades. In
contrast, extending the same approach to achieve activation of the distal meta‐and para‐C …
contrast, extending the same approach to achieve activation of the distal meta‐and para‐C …
Recent development in transition metal-catalysed C–H olefination
Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds
represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of …
represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of …
The crucial role of silver (i)-salts as additives in C–H activation reactions: overall analysis of their versatility and applicability
RL de Carvalho, EBT Diogo, SL Homölle… - Chemical Society …, 2023 - pubs.rsc.org
Transition-metal catalyzed C–H activation reactions have been proven to be useful
methodologies for the assembly of synthetically meaningful molecules. This approach bears …
methodologies for the assembly of synthetically meaningful molecules. This approach bears …
Pd-catalyzed regioselective activation of C (sp 2)–H and C (sp 3)–H bonds
Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …
Decoding directing groups and their pivotal role in C− H activation
K Murali, LA Machado, RL Carvalho… - … A European Journal, 2021 - Wiley Online Library
Synthetic organic chemistry has witnessed a plethora of functionalization and
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …
defunctionalization strategies. In this regard, C− H functionalization has been at the forefront …
Dual Ligand Enabled Nondirected C–H Chalcogenation of Arenes and Heteroarenes
Chalcogenide motifs are present as principal moieties in a vast array of natural products and
complex molecules. Till date, the construction of these chalcogen motifs has been restricted …
complex molecules. Till date, the construction of these chalcogen motifs has been restricted …