Massive blood loss leading to hypovolemic shock is still a life-threatening situation.
Recently, a great number of investigations have been conducted in order to understand the …

Shock resulting from life-threatening blood loss (hemorrhage) remains a common
complication of traumatic injury. Intensive experimental efforts are needed if we are to …

Treatment of polytrauma patients remains a medical as well as socioeconomic challenge.
Although diagnostics and therapy improved during the last decades, multiple injuries are still …

Hemorrhage is a leading cause of death following traumatic injuries in the United States.
Much of the previous work in assessing the physiology and pathophysiology underlying …

Physiological compensatory mechanisms can mask the extent of hemorrhage in conscious
mammals, which can be further complicated by individual tolerance and variations in …

Neurocardiogenic syncope (NCS, simple fainting) is a common and typically benign familial
condition, which rarely may result in traumatic injury or hypoxic convulsions. NCS is …

Background The activity of autonomic nervous system and its association with organ
damage have not been entirely elucidated in hemorrhagic shock. The aim of this study was …

Previous research has suggested that the ventrolateral column of the periaqueductal gray
(vlPAG) plays a crucial role in triggering a decompensatory response (sympathoinhibition …

This study was undertaken to evaluate heart rate (HR) regulation during severe hemorrhage
(HEM) at different rates of blood loss. Chronically instrumented male rats underwent HEM at …

Here we report the involvement of N-Methyl-d-Aspartate (NMDA) and non-NMDA glutamate
receptors from the paraventricular nucleus of the hypothalamus (PVN) in the mediation of …