[HTML][HTML] Polymeric micelles in drug delivery: An insight of the techniques for their characterization and assessment in biorelevant conditions

M Ghezzi, S Pescina, C Padula, P Santi… - Journal of Controlled …, 2021 - Elsevier
Polymeric micelles, ie aggregation colloids formed in solution by self-assembling of
amphiphilic polymers, represent an innovative tool to overcome several issues related to …

Artificial intelligence and machine learning in computational nanotoxicology: unlocking and empowering nanomedicine

AV Singh, MHD Ansari, D Rosenkranz… - Advanced …, 2020 - Wiley Online Library
Advances in nanomedicine, coupled with novel methods of creating advanced materials at
the nanoscale, have opened new perspectives for the development of healthcare and …

[HTML][HTML] Phytosomal nanocarriers as platforms for improved delivery of natural antioxidant and photoprotective compounds in propolis: An approach for enhanced both …

AD Permana, RN Utami, AJ Courtenay… - … of photochemistry and …, 2020 - Elsevier
Propolis has been reported to possess rich content of antioxidant compounds and may
provide health benefits through oxidative stress reduction. Presently, the formulation …

Physiologically based pharmacokinetic modeling of nanoparticles

D Yuan, H He, Y Wu, J Fan, Y Cao - Journal of pharmaceutical sciences, 2019 - Elsevier
Nanoparticles are frequently designed to improve the pharmacokinetics profiles and tissue
distribution of small molecules to prolong their systemic circulation, target specific tissue, or …

Integration of in vitro and in vivo models to predict cellular and tissue dosimetry of nanomaterials using physiologically based pharmacokinetic modeling

Z Lin, S Aryal, YH Cheng, AJ Gesquiere - ACS nano, 2022 - ACS Publications
Nanomaterials (NMs) have been increasingly used in a number of areas, including
consumer products and nanomedicine. Target tissue dosimetry is important in the evaluation …

Nanomedicines-tiny particles and big challenges

MRC Marques, Q Choo, M Ashtikar, TC Rocha… - Advanced Drug Delivery …, 2019 - Elsevier
After decades of research, nanotechnology has been used in a broad array of biomedical
products including medical devices, drug products, drug substances, and pharmaceutical …

Opportunities and challenges of physiologically based pharmacokinetic modeling in drug delivery

W Wang, D Ouyang - Drug Discovery Today, 2022 - Elsevier
Highlights•PBPK modeling bridges drug properties and PK behaviours in drug discovery
and development.•The PBPK is often used in oral formulation development, to address …

Effects of nanoplastics on clam Ruditapes philippinarum at environmentally realistic concentrations: toxicokinetics, toxicity, and gut microbiota

Y Zhou, C Wu, Y Li, H Jiang, A Miao, Y Liao… - Journal of Hazardous …, 2023 - Elsevier
Nanoplastics are ubiquitous in marine environments, understanding to what extent
nanoplastics accumulate in bivalves and the adverse effects derived from their retention is …

Nanomedicine at the crossroads–a quick guide for IVIVC

MP Mast, H Modh, C Champanhac, JW Wang… - Advanced drug delivery …, 2021 - Elsevier
For many years, nanomedicine is pushing the boundaries of drug delivery. When applying
these novel therapeutics, safety considerations are not only a key concern when entering …

Nanopharmaceuticals for wound healing–lost in translation?

M Ashtikar, MG Wacker - Advanced drug delivery reviews, 2018 - Elsevier
Today, many of the newly developed pharmaceuticals and medical devices take advantage
of nanotechnology and with a rising incidence of chronic diseases such as diabetes and …