TP53 is a critical tumor-suppressor gene that is mutated in more than half of all human
cancers. Mutations in TP53 not only impair its antitumor activity, but also confer mutant p53 …

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has
been a major focus of oncology research. The p53 protein is a transcription factor that can …

With advances in chemically induced proximity technologies, heterobifunctional modalities
such as proteolysis targeting chimeras (PROTACs) have been successfully advanced to …

The tumor suppressor protein p53 is inactivated in the majority of human cancers and
remains a prime target for develo** new drugs to reactivate its tumor suppressing activity …

In response to genotoxic stress, the tumor suppressor p53 acts as a transcription factor by
regulating the expression of genes critical for cancer prevention. Mutations in the gene …

Simple Summary Cancer is largely caused by genetic alterations such as mutations in a
group of genes known as cancer driver genes. Many of the key advances in cancer …

Abstract The N 6-methyladenosine (m6A) modification is found in thousands of cellular
mRNAs and is a critical regulator of gene expression and cellular physiology. m6A …

Simple Summary The tumor suppressor protein p53 is frequently mutated in human cancers,
and its reactivation represents an encouraging hope for precision anticancer therapy …

TP53 is a tumor suppressor gene that encodes a sequence-specific DNA-binding
transcription factor activated by stressful stimuli; it upregulates target genes involved in …

The p53 protein has appropriately been named the “guardian of the genome”. In almost all
human cancers, the powerful tumor suppressor function of p53 is compromised by a variety …