Men are at greater risk for cardiovascular and renal disease than are age-matched,
premenopausal women. Recent studies using the technique of 24-hour ambulatory blood …

The renin-angiotensin system (RAS) is a coordinated hormonal cascade in the control of
cardiovascular, renal, and adrenal function that governs body fluid and electrolyte balance …

The renin-angiotensin system is a major physiological regulator of body fluid volume,
electrolyte balance, and arterial pressure. Virtually all of the biological actions of the …

Angiotensin II (Ang II) plays an important role in regulating cardiovascular hemodynamics
and structure. Multiple lines of evidence have suggested the existence of Ang II receptor …

Since the discovery of nonpeptidic ligands, the receptors for angiotensin (Ang) II have been
classified into 2 subtypes (Ang II type 1 receptor [AT1-R] and Ang II type 2 receptor [AT2-R]) …

Renoprotective benefits of RAS inhibition: From ACEI to angiotensin II antagonists. In
landmark clinical trials, pharmacological inhibition of the renin-angiotensin system (RAS) …

Angiotensin II (Ang II) is a potent vasopressor peptide that interacts with 2 major receptor
isoforms—AT1 and AT2. Although blood pressure is increased in AT2 knockout mice, the …

Angiotensin II (Ang II) is a multi-functional hormone that plays a major role in regulating
blood pressure and cardiovascular homoeostasis. The actions of Ang II are mediated by at …

In diabetes mellitus (DM), the circulating renin–angiotensin system (RAS) is suppressed, but
the renal tissue RAS is activated. Hyperglycemia increases tissue angiotensin II (Ang II) …

ANG II contributes importantly to the regulation of renal vascular resistance, glomerular
filtration, and tubular epithelial transport, yet there remains a paucity of information regarding …