Roles of tumor-associated macrophages in anti-PD-1/PD-L1 immunotherapy for solid cancers
H Zhang, L Liu, J Liu, P Dang, S Hu, W Yuan, Z Sun… - Molecular Cancer, 2023 - Springer
In recent years, tumor immunotherapy has made significant progress. However, tumor
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
immunotherapy, particularly immune checkpoint inhibitors (eg, PD-1/PD-L1 inhibitors) …
The biology of TREM receptors
M Colonna - Nature Reviews Immunology, 2023 - nature.com
Triggering receptors expressed on myeloid cells (TREMs) encompass a family of cell-
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …
surface receptors chiefly expressed by granulocytes, monocytes and tissue macrophages …
Targeting tumor-associated macrophages to synergize tumor immunotherapy
X **ang, J Wang, D Lu, X Xu - Signal transduction and targeted therapy, 2021 - nature.com
The current treatment strategies in advanced malignancies remain limited. Notably,
immunotherapies have raised hope for a successful control of these advanced diseases, but …
immunotherapies have raised hope for a successful control of these advanced diseases, but …
Immunotherapy in colorectal cancer: rationale, challenges and potential
Following initial successes in melanoma treatment, immunotherapy has rapidly become
established as a major treatment modality for multiple types of solid cancers, including a …
established as a major treatment modality for multiple types of solid cancers, including a …
Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease
The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has
accelerated research into the role of microglia in AD. While TREM2 mouse models have …
accelerated research into the role of microglia in AD. While TREM2 mouse models have …
The physiology, pathology, and potential therapeutic applications of the TREM2 signaling pathway
Alzheimer's disease, obesity-related metabolic syndrome, and cancer are the leading
causes of death and among the most costly medical conditions in the Western world. In all …
causes of death and among the most costly medical conditions in the Western world. In all …
Disease-associated microglia: a universal immune sensor of neurodegeneration
A major challenge in the field of neurodegenerative diseases and brain aging is to identify
the body's intrinsic mechanism that could sense the central nervous system (CNS) damage …
the body's intrinsic mechanism that could sense the central nervous system (CNS) damage …
Microglia and macrophages in brain homeostasis and disease
Q Li, BA Barres - Nature Reviews Immunology, 2018 - nature.com
Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that
are increasingly recognized to be essential players in the development, homeostasis and …
are increasingly recognized to be essential players in the development, homeostasis and …
TREM2 dependent and independent functions of microglia in Alzheimer's disease
Microglia are central players in brain innate immunity and have been the subject of
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …
extensive research in Alzheimer's disease (AD). In this review, we aim to summarize the …
Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model
TREM2 is a receptor for lipids expressed in microglia. The R47H variant of human TREM2
impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of …
impairs ligand binding and increases Alzheimer's disease (AD) risk. In mouse models of …