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Biological aging processes underlying cognitive decline and neurodegenerative disease
Alzheimer's disease and related dementias (ADRD) are among the top contributors to
disability and mortality in later life. As with many chronic conditions, aging is the single most …
disability and mortality in later life. As with many chronic conditions, aging is the single most …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
A computational solution for bolstering reliability of epigenetic clocks: implications for clinical trials and longitudinal tracking
Epigenetic clocks are widely used aging biomarkers calculated from DNA methylation data,
but this data can be surprisingly unreliable. Here we show that technical noise produces …
but this data can be surprisingly unreliable. Here we show that technical noise produces …
A complex systems approach to aging biology
Having made substantial progress understanding molecules, cells, genes and pathways,
aging biology research is now moving toward integration of these parts, attempting to …
aging biology research is now moving toward integration of these parts, attempting to …
The relationship between epigenetic age and the hallmarks of aging in human cells
Epigenetic clocks are mathematically derived age estimators that are based on
combinations of methylation values that change with age at specific CpGs in the genome …
combinations of methylation values that change with age at specific CpGs in the genome …
Chemically induced reprogramming to reverse cellular aging
A hallmark of eukaryotic aging is a loss of epigenetic information, a process that can be
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
reversed. We have previously shown that the ectopic induction of the Yamanaka factors …
[HTML][HTML] 60 years of healthy aging: on definitions, biomarkers, scores and challenges
Background and objective As the proportion of aging people in our population increases
steadily, global strategies accompanied by extensive research are necessary to tackle …
steadily, global strategies accompanied by extensive research are necessary to tackle …
PRC2-AgeIndex as a universal biomarker of aging and rejuvenation
DNA methylation (DNAm) is one of the most reliable biomarkers of aging across mammalian
tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm …
tissues. While the age-dependent global loss of DNAm has been well characterized, DNAm …
Epigenetic aging: Biological age prediction and informing a mechanistic theory of aging
Numerous studies have shown that epigenetic age—an individual's degree of aging based
on patterns of DNA methylation—can be computed and is associated with an array of factors …
on patterns of DNA methylation—can be computed and is associated with an array of factors …
Associations of age, sex, race/ethnicity, and education with 13 epigenetic clocks in a nationally representative US sample: the Health and Retirement Study
Background Many DNA methylation-based indicators have been developed as summary
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …
measures of epigenetic aging. We examine the associations between 13 epigenetic clocks …