The initial hepatitis B virus-hepatocyte genomic integrations and their role in hepatocellular oncogenesis

TI Michalak - International Journal of Molecular Sciences, 2023 - mdpi.com
Hepatitis B virus (HBV) remains a dominant cause of hepatocellular carcinoma (HCC).
Recently, it was shown that HBV and woodchuck hepatitis virus (WHV) integrate into the …

[HTML][HTML] The role of hepatocyte mitochondrial DNA in liver injury

Y Xu, C Chu, Z Shi, J Zhang - Biomedicine & Pharmacotherapy, 2023 - Elsevier
Hepatocytes, the predominant cellular constituents of the liver, exhibit the highest
mitochondrial density within the human body. Remarkably, experimental insights from the …

Polyribonucleotide nucleotidyltransferase 1 participates in metabolic-associated fatty liver disease pathogenesis by affecting lipid metabolism and mitochondrial …

C Guan, X Zou, C Yang, W Shi, J Gao, Y Ge, Z Xu… - Molecular …, 2024 - Elsevier
Objective Metabolic-associated fatty liver disease (MAFLD) represents one of the most
prevalent chronic liver conditions worldwide, but its precise pathogenesis remains unclear …

Altered mitochondrial mass and low mitochondrial membrane potential of immune cells in patients with HBV infection and correlation with liver inflammation

L Ma, Q Han, L Cheng, H Song, R Qiang, P Xu… - Frontiers in …, 2024 - frontiersin.org
Introduction Mitochondrial membrane potential (MMP) and mitochondrial mass (MM) affect
mitochondrial function and lymphocyte activation, but few studies on HBV infection exist …

Mitochondrial oxidative phosphorylation in viral infections

N Purandare, E Ghosalkar, LI Grossman, S Aras - Viruses, 2023 - mdpi.com
Mitochondria have been identified as the “powerhouse” of the cell, generating the cellular
energy, ATP, for almost seven decades. Research over time has uncovered a multifaceted …

Regulation of Mitochondrial Metabolism by Hepatitis B Virus

Y Li, JJ Ou - Viruses, 2023 - mdpi.com
Mitochondria play important roles in the synthesis of ATP, the production of reactive oxygen
species, and the regulation of innate immune response and apoptosis. Many viruses perturb …

Intra-host genomic diversity and integration landscape of human tissue-resident DNA virome

L Pyöriä, D Pratas, M Toppinen… - Nucleic Acids …, 2024 - academic.oup.com
The viral intra-host genetic diversities and interactions with the human genome during
decades of persistence remain poorly characterized. In this study, we analyzed the …

The impact of integrated hepatitis B virus DNA on oncogenesis and antiviral therapy

M Zhang, H Chen, H Liu, H Tang - Biomarker Research, 2024 - Springer
The global burden of hepatitis B virus (HBV) infection remains high, with chronic hepatitis B
(CHB) patients facing a significantly increased risk of develo** cirrhosis and …

[HTML][HTML] Resolution of Optimal Mitochondrial and Nuclear DNA Enrichment in Target-Panel Sequencing and Physiological Mitochondrial DNA Copy Number …

XY Lyu, YM Tsui, IKK Tam, PM Li, GCH Cheung… - Cancers, 2024 - mdpi.com
Simple Summary Mitochondria are important organelles in the human body, and they act as
a source of chemical energy for different cellular processes. Multiple copies of mitochondria …

Altered counts and mitochondrial mass of peripheral blood leucocytes in patients with chronic hepatitis B virus infection

RR Zhou, YH Song, CY Xu, YY Zhang… - Journal of Cellular …, 2024 - Wiley Online Library
Hepatitis B virus (HBV) damages liver cells through abnormal immune responses.
Mitochondrial metabolism is necessary for effector functions of white blood cells (WBCs) …