Engineering precision nanoparticles for drug delivery

MJ Mitchell, MM Billingsley, RM Haley… - Nature reviews drug …, 2021 - nature.com
In recent years, the development of nanoparticles has expanded into a broad range of
clinical applications. Nanoparticles have been developed to overcome the limitations of free …

Where is nano today and where is it headed? A review of nanomedicine and the dilemma of nanotoxicology

C Domingues, A Santos, C Alvarez-Lorenzo… - ACS …, 2022 - ACS Publications
Worldwide nanotechnology development and application have fueled many scientific
advances, but technophilic expectations and technophobic demands must be …

Delivery technologies for cancer immunotherapy

RS Riley, CH June, R Langer, MJ Mitchell - Nature reviews Drug …, 2019 - nature.com
Immunotherapy has become a powerful clinical strategy for treating cancer. The number of
immunotherapy drug approvals has been increasing, with numerous treatments in clinical …

Blood-brain barrier and delivery of protein and gene therapeutics to brain

WM Pardridge - Frontiers in aging neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) and treatment of the brain in aging require the development of
new biologic drugs, such as recombinant proteins or gene therapies. Biologics are large …

In situ programming of leukaemia-specific T cells using synthetic DNA nanocarriers

TT Smith, SB Stephan, HF Moffett, LE McKnight… - Nature …, 2017 - nature.com
An emerging approach for treating cancer involves programming patient-derived T cells with
genes encoding disease-specific chimeric antigen receptors (CARs), so that they can …

Ligand‐installed nanocarriers toward precision therapy

P Mi, H Cabral, K Kataoka - Advanced Materials, 2020 - Wiley Online Library
Abstract Development of drug‐delivery systems that selectively target neoplastic cells has
been a major goal of nanomedicine. One major strategy for achieving this milestone is to …

Genetic programming of macrophages to perform anti-tumor functions using targeted mRNA nanocarriers

F Zhang, NN Parayath, CI Ene, SB Stephan… - Nature …, 2019 - nature.com
Tumor-associated macrophages (TAMs) usually express an M2 phenotype, which enables
them to perform immunosuppressive and tumor-promoting functions. Reprogramming these …

Glioblastoma: current status, emerging targets, and recent advances

A Thakur, C Faujdar, R Sharma, S Sharma… - Journal of Medicinal …, 2022 - ACS Publications
Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma

W Mao, K Wang, B Xu, H Zhang, S Sun, Q Hu, L Zhang… - Molecular Cancer, 2021 - Springer
Circular RNAs are a new class of non-coding RNAs that have been shown to play critical
roles in the development and progression of renal cell carcinoma (RCC). However, little is …

Therapeutic applications of nanobiotechnology

Y Dutt, RP Pandey, M Dutt, A Gupta, A Vibhuti… - Journal of …, 2023 - Springer
Nanobiotechnology, as a novel and more specialized branch of science, has provided a
number of nanostructures such as nanoparticles, by utilizing the methods, techniques, and …