Challenges of peptide and protein drug delivery by oral route: Current strategies to improve the bioavailability
S Verma, UK Goand, A Husain… - Drug development …, 2021 - Wiley Online Library
Advancement in biotechnology provided a notable expansion of peptide and protein
therapeutics, used as antigens, vaccines, hormones. It has a prodigious potential to treat a …
therapeutics, used as antigens, vaccines, hormones. It has a prodigious potential to treat a …
Microneedle mediated transdermal delivery of protein, peptide and antibody based therapeutics: current status and future considerations
The success of protein, peptide and antibody based therapies is evident-the
biopharmaceuticals market is predicted to reach $388 billion by 2024 [1], and more than half …
biopharmaceuticals market is predicted to reach $388 billion by 2024 [1], and more than half …
Dual functionalized liposome-mediated gene delivery across triple co-culture blood brain barrier model and specific in vivo neuronal transfection
B dos Santos Rodrigues, H Oue, A Banerjee… - Journal of controlled …, 2018 - Elsevier
Gene therapy has become a promising approach for neurodegenerative disease treatment,
however there is an urgent need to develop an efficient gene carrier to transport gene …
however there is an urgent need to develop an efficient gene carrier to transport gene …
[HTML][HTML] Use of protamine in nanopharmaceuticals—a review
I Ruseska, K Fresacher, C Petschacher, A Zimmer - Nanomaterials, 2021 - mdpi.com
Macromolecular biomolecules are currently dethroning classical small molecule
therapeutics because of their improved targeting and delivery properties. Protamine-a small …
therapeutics because of their improved targeting and delivery properties. Protamine-a small …
Surface modification of lipid-based nanocarriers for cancer cell-specific drug targeting
Targeted drug delivery systems using nanocarriers for anticancer drugs have been
investigated for over several decades. Among the many nanocarrier systems, lipid-based …
investigated for over several decades. Among the many nanocarrier systems, lipid-based …
Novel strategies in the oral delivery of antidiabetic peptide drugs–Insulin, GLP 1 and its analogs
R Ismail, I Csóka - European journal of pharmaceutics and …, 2017 - Elsevier
As diabetes is a complex disorder being a major cause of mortality and morbidity in
epidemic rates, continuous research has been done on new drug types and administration …
epidemic rates, continuous research has been done on new drug types and administration …
Bile acid transporter-mediated oral absorption of insulin via hydrophobic ion-pairing approach
Despite many ongoing and innovative approaches, there are still formidable challenges in
the clinical translation of oral peptide drugs into marketable products due to their low …
the clinical translation of oral peptide drugs into marketable products due to their low …
Effect of the lipid landscape on the efficacy of cell-penetrating peptides
Every cell biological textbook teaches us that the main role of the plasma membrane is to
separate cells from their neighborhood to allow for a controlled composition of the …
separate cells from their neighborhood to allow for a controlled composition of the …
Development and screening of brain-targeted lipid-based nanoparticles with enhanced cell penetration and gene delivery properties
B dos Santos Rodrigues, S Lakkadwala… - International journal …, 2019 - Taylor & Francis
Background The potential of gene therapy for treatment of neurological disorders can be
explored using designed lipid-based nanoparticles such as liposomes, which have …
explored using designed lipid-based nanoparticles such as liposomes, which have …
Critical material designs for mucus-and mucosa-penetrating oral insulin nanoparticle development
Subcutaneous and pulmonary insulin is associated with medical and pharmaceutical
complications. Oral insulin mimics physiological glucose regulation with reduced …
complications. Oral insulin mimics physiological glucose regulation with reduced …