Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of
the most extensively studied signaling kinases. PKCs signal through multiple pathways and …

The surface of a cell represents a collection of macromolecules, which provides the cell with
a unique cellular landscape specific to the type and state of the cell. Ligands that …

Increased production of proinflammatory cytokines has a prominent role in tolerance to
opioids. The objectives of this study were to examine whether μ‐opioid receptor affects …

Protein kinase C ϵ (PKCϵ) has emerged as an oncogenic kinase and plays important roles
in cell survival, mitogenesis and invasion. PKCϵ is up-regulated in most epithelial cancers …

The protein kinase C (PKC) family proteins are important signal transducers and have long
been the focus of cancer research. PKCɛ, a member of this family, is overexpressed in most …

Chemoresistant cancer cells express high levels of aldehyde dehydrogenases (ALDHs),
particularly in head and neck squamous cell carcinoma (HNSCC). The ALDH family of …

Metastasis remains a major cause of mortality in patients with head and neck squamous cell
carcinoma (HNSCC). HNSCC patients with metastatic disease have extremely poor …

The bone is a preferred site for metastatic homing of prostate cancer cells. Once prostate
cancer patients develop skeletal metastases, they eventually succumb to the disease; …

The second-generation oral heat shock protein inhibitor Debio0932 showed almost linear
pharmacokinetics and some clinical activity along with manageable toxicity, particularly in …

Abstract HN-1, a 12-amino acid peptide, has been reported to possess strong capabilities for
targeting and penetrating head and neck squamous cell carcinoma. Here, we designed a …