Osteosarcoma (OS) is the most common primary bone malignancy and responsible for
considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These
proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell …

Snake venom disintegrins are low molecular weight, non-enzymatic proteins rich in cysteine,
present in the venom of snakes from the families Viperidae, Crotalidae, Atractaspididae …

While integrins were originally discovered as cell adhesion receptors, recent studies have
reinforced the concept that integrins have central roles in cancer that extend far beyond …

Snake venoms are a potential source of various enzymatic and non-enzymatic compounds
with a defensive role for the host. Various peptides with significant medicinal properties have …

Breast cancer is characterized by a hypoxic microenvironment inside the tumor mass,
contributing to cell metastatic behavior. Hypoxia induces the expression of hypoxia …

L-amino acid oxidase (LAAO) is a protein toxin commonly found in snake venom. It has
many applications, ranging from biotechnology to potential anticancer therapeutics. LAAO …

Snake venoms represent an adaptive trophic response to the challenges confronting a
limbless predator for overcoming combative prey, and this chemical means of subduing prey …

Vitamin C is an electron donor and is involved in a variety of biochemical reactions in stem
cell and cancer stem cell, as well as collagen synthesis and the regulation of hypoxia …