Schizophrenia has been conceptualized as a neurodevelopmental disorder with synaptic
alterations and aberrant cortical–subcortical connections. Antipsychotics are the mainstay of …

Objective To integrate all evidence derived from randomized controlled trials (RCTs) of both
pharmacological and nonpharmacological augmentation interventions for clozapine …

During adolescence, the brain undergoes extensive changes in white matter structure that
support cognition. Data-driven approaches applied to cortical surface properties have led …

This systematic review aimed to review neuroimaging studies comparing clozapine-resistant
schizophrenia patients with clozapine-responding patients, and with first-line antipsychotic …

Abstract Background and Hypothesis Given the heterogeneity and possible disease
progression in schizophrenia, identifying the neurobiological subtypes and progression …

Background Electroconvulsive therapy (ECT) is one of the most effective treatments for
depression and schizophrenia, particularly in urgent or treatment-resistant cases. After ECT …

Abstract Few studies using Positron Emission Tomography with 18F-fluorodeoxyglucose
(18F-FDG-PET) have examined the neurobiological basis of antipsychotic resistance in …

Treatment-resistance in patients with schizophrenia is a major obstacle for improving
outcome in patients, especially in those not gaining from clozapine. Novel research implies …

Background Research suggests structural and connectivity abnormalities in patients with
treatment-resistant schizophrenia (TRS) compared to first-line responders and healthy …

Regional variations in glutamate levels across the cingulate cortex, decreasing rostral to
caudal, have been observed previously in healthy volunteers with proton magnetic …