Zoonosis and zooanthroponosis of emerging respiratory viruses

AM Khalil, L Martinez-Sobrido… - Frontiers in Cellular and …, 2024 - frontiersin.org
Lung infections in Influenza-Like Illness (ILI) are triggered by a variety of respiratory viruses.
All human pandemics have been caused by the members of two major virus families …

SARS-CoV-2 and the DNA damage response

RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …

Unraveling the role of the nucleocapsid protein in SARS-CoV-2 pathogenesis: From viral life cycle to vaccine development

YA El-Maradny, MA Badawy, KI Mohamed… - International Journal of …, 2024 - Elsevier
Background The nucleocapsid protein (N protein) is the most abundant protein in SARS-
CoV-2. Viral RNA and this protein are bound by electrostatic forces, forming cytoplasmic …

Genomic Surveillance and Mutation Analysis of SARS-CoV-2 Variants among Patients in Saudi Arabia

FA Alsuwairi, AN Alsaleh, DA Obeid, AA Al-Qahtani… - Microorganisms, 2024 - mdpi.com
The genome of severe acute respiratory coronavirus-2 (SARS-CoV-2), the virus responsible
for coronavirus disease 2019 (COVID-19), has undergone a rapid evolution, resulting in the …

Analysis of the structure and interactions of the SARS-CoV-2 ORF7b accessory protein

MH Nguyen, G Palfy, ML Fogeron… - Proceedings of the …, 2024 - pnas.org
SARS-CoV-2 carries a sizeable number of proteins that are accessory to replication but may
be essential for virus–host interactions and modulation of the host immune response. Here …

3-chymotrypsin-like protease in SARS-CoV-2

K Al Adem, JC Ferreira, AJ Villanueva, S Fadl… - Bioscience …, 2024 - portlandpress.com
Coronaviruses constitute a significant threat to the human population. Severe acute
respiratory syndrome coronavirus-2, SARS-CoV-2, is a highly pathogenic human …

A multifaceted approach for identification, validation, and immunogenicity of naturally processed and in silico-predicted highly conserved SARS-CoV-2 peptides

T Ratishvili, HQ Quach, IH Haralambieva… - Vaccine, 2024 - Elsevier
SARS-CoV-2 remains a major global public health concern. Antibody waning and immune
escape variant emergence necessitate the development of next generation vaccines that …

[HTML][HTML] Inhalation phage therapy as a new approach to preventing secondary bacterial pneumonia in patients with moderate to severe COVID-19: A double-blind …

HR Samaee, G Eslami, G Rahimzadeh… - Journal of Drug Delivery …, 2023 - Elsevier
Inhalation phage therapy is proposed as a replacement approach for antibiotics in the
treatment of pulmonary bacterial infections. This study investigates phage therapy on …

[HTML][HTML] Advances in the Search for SARS-CoV-2 Mpro and PLpro Inhibitors

MA Diogo, AGT Cabral, RB de Oliveira - Pathogens, 2024 - mdpi.com
SARS-CoV-2 is a spherical, positive-sense, single-stranded RNA virus with a large genome,
responsible for encoding both structural proteins, vital for the viral particle's architecture, and …

An isothermal calorimetry assay for determining steady state kinetic and Ensitrelvir inhibition parameters for SARS-CoV-2 3CL-protease

L Mazzei, S Ranieri, D Silvestri, R Greene-Cramer… - Scientific Reports, 2024 - nature.com
This manuscript details the application of Isothermal Titration Calorimetry (ITC) to
characterize the kinetics of 3CLpro, the main protease from the Severe Acute Respiratory …