Multifaceted mitochondria: moving mitochondrial science beyond function and dysfunction
AS Monzel, JA Enríquez, M Picard - Nature metabolism, 2023 - nature.com
Mitochondria have cell-type specific phenotypes, perform dozens of interconnected
functions and undergo dynamic and often reversible physiological recalibrations. Given their …
functions and undergo dynamic and often reversible physiological recalibrations. Given their …
The emerging mechanisms and functions of microautophagy
L Wang, DJ Klionsky, HM Shen - Nature Reviews Molecular Cell …, 2023 - nature.com
Abstract 'Autophagy'refers to an evolutionarily conserved process through which cellular
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
contents, such as damaged organelles and protein aggregates, are delivered to lysosomes …
[HTML][HTML] Fumarate induces vesicular release of mtDNA to drive innate immunity
V Zecchini, V Paupe, I Herranz-Montoya, J Janssen… - Nature, 2023 - nature.com
Mutations in fumarate hydratase (FH) cause hereditary leiomyomatosis and renal cell
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
carcinoma. Loss of FH in the kidney elicits several oncogenic signalling cascades through …
Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
Mitochondria at the crossroads of health and disease
A Suomalainen, J Nunnari - Cell, 2024 - cell.com
Mitochondria reside at the crossroads of catabolic and anabolic metabolism—the essence of
life. How their structure and function are dynamically tuned in response to tissue-specific …
life. How their structure and function are dynamically tuned in response to tissue-specific …
Mitochondrial oxidative stress in the tumor microenvironment and cancer immunoescape: foe or friend?
CL Kuo, A Ponneri Babuharisankar, YC Lin… - Journal of biomedical …, 2022 - Springer
The major concept of" oxidative stress" is an excess elevated level of reactive oxygen
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …
species (ROS) which are generated from vigorous metabolism and consumption of oxygen …
Molecular mechanisms of mitochondrial dynamics
Mitochondria not only synthesize energy required for cellular functions but are also involved
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …
in numerous cellular pathways including apoptosis, calcium homoeostasis, inflammation …
PINK1/Parkin-mediated mitophagy in neurodegenerative diseases
J Li, D Yang, Z Li, M Zhao, D Wang, Z Sun, P Wen… - Ageing research …, 2023 - Elsevier
Mitochondria play key roles in bioenergetics, metabolism, and signaling; therefore, stable
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …
mitochondrial function is essential for cell survival, particularly in energy-intensive neuronal …
Mitochondria as cellular and organismal signaling hubs
Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …
extend far beyond energy production. They are vital in cellular and organismal pathways …
Mitochondrial quality control in health and in Parkinson's disease
As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …
pivotal organelle, dysfunction of which has been linked to several human diseases including …