Molecular characterization of vascular anomalies has revealed that affected endothelial
cells (ECs) harbor gain-of-function (GOF) mutations in the gene encoding the catalytic α …

Brain arteriovenous malformation (BAVM) is a rare but serious cerebrovascular disease
whose pathogenesis has not been fully elucidated. Studies have found that epigenetic …

Telangiectases and arteriovenous malformations (AVMs) are the characteristic lesions of
Hereditary Hemorrhagic Telangiectasia (HHT). Somatic second-hit loss-of-function …

Cerebral cavernous malformations (CCMs) are hemorrhagic vascular disorders with varied
clinical and radiological presentations, occurring sporadically due to MAP3K3 or PIK3CA …

Somatic activating mutations in PIK3CA are common drivers of vascular and lymphatic
malformations. Despite common biophysical signatures of tissues susceptible to lesion …

Cerebral vascular malformations (CVMs), particularly cerebral cavernous malformations and
cerebral arteriovenous malformations, pose significant neurological challenges due to their …

Background Cerebral cavernous malformation (CCM) is a low-flow, bleeding-prone vascular
disease that can cause cerebral hemorrhage, seizure and neurological deficits. Its …

Introduction Cerebral cavernous malformation (CCM) is a type of cerebrovascular
abnormality in the central nervous system linked to both germline and somatic genetic …

Dear Editor, Our study suggested that in familial multiple cerebral cavernous malformations
(CCMs), symptomatic intracerebral haemorrhage (ICH) lesions and dot-sized lesions …

Brain endothelial cells are critical for homeostasis of the central nervous system. Novel
adeno-associated viruses (AAV) with brain endothelial cell tropism have been developed …