[HTML][HTML] Age-related macular degeneration: Epidemiology, genetics, pathophysiology, diagnosis, and targeted therapy

Y Deng, L Qiao, M Du, C Qu, L Wan, J Li, L Huang - Genes & diseases, 2022 - Elsevier
Age-related macular degeneration (AMD) is a complex eye disorder and is the leading
cause of incurable blindness worldwide in the elderly. Clinically, AMD initially affects the …

Molecular pathology of age-related macular degeneration

X Ding, M Patel, CC Chan - Progress in retinal and eye research, 2009 - Elsevier
Age-related macular degeneration (AMD) is a leading cause of irreversible blindness in the
world. Although the etiology and pathogenesis of AMD remain largely unclear, a complex …

Dysfunctional autophagy in RPE, a contributing factor in age-related macular degeneration

N Golestaneh, Y Chu, YY **ao, GL Stoleru… - Cell death & …, 2018 - nature.com
Age-related macular degeneration (AMD) is a devastating neurodegenerative disease and a
major cause of blindness in the developed world. Owing to its complexity and the lack of an …

Subretinal drusenoid deposits in non-neovascular age-related macular degeneration: morphology, prevalence, topography, and biogenesis model

CA Curcio, JD Messinger, KR Sloan, G McGwin… - Retina, 2013 - journals.lww.com
Purpose: To characterize the morphology, prevalence, and topography of subretinal
drusenoid deposits, a candidate histological correlate of reticular pseudodrusen, with …

The oil spill in ageing Bruch membrane

CA Curcio, M Johnson, M Rudolf… - British Journal of …, 2011 - bjo.bmj.com
Ageing is the largest risk factor for age-related macular degeneration (AMD), and soft drusen
and basal linear deposits are lipid-rich extracellular lesions specific to AMD. Oil red O …

Cholesterol in the retina: the best is yet to come

IA Pikuleva, CA Curcio - Progress in retinal and eye research, 2014 - Elsevier
Historically understudied, cholesterol in the retina is receiving more attention now because
of genetic studies showing that several cholesterol-related genes are risk factors for age …

Age-related macular degeneration (AMD): Alzheimer's disease in the eye?

K Kaarniranta, A Salminen… - Journal of …, 2011 - content.iospress.com
Age-related macular degeneration (AMD) is a late-onset, neurodegenerative retinal disease
that shares several clinical and pathological features with Alzheimer's disease (AD) …

Cell culture models of the ocular barriers

M Hornof, E Toropainen, A Urtti - European journal of pharmaceutics and …, 2005 - Elsevier
The presence of tight barriers, which regulate the environment of ocular tissues in the
anterior and posterior part of the eye, is essential for normal visual function. The …

Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins

CA Curcio, M Johnson, JD Huang, M Rudolf - Progress in retinal and eye …, 2009 - Elsevier
The largest risk factor for age-related macular degeneration (ARMD) is advanced age. A
prominent age-related change in the human retina is the accumulation of histochemically …

On phagocytes and macular degeneration

X Guillonneau, CM Eandi, M Paques, JA Sahel… - Progress in retinal and …, 2017 - Elsevier
Age related macular degeneration (AMD) is a complex multifactorial disease caused by the
interplay of age and genetic and environmental risk factors. A common feature observed in …