New insights into the bioactive polysaccharides, proteins, and triterpenoids isolated from bitter melon (Momordica charantia) and their relevance for nutraceutical and …

AFM Bora, KJEP Kouame, X Li, L Liu, Y Pan - International Journal of …, 2023 - Elsevier
The recent trend in infectious diseases and chronic disorders has dramatically increased
consumers' interest in functional foods. As a result, the research of bioactive ingredients with …

Three Selected Edible Crops of the Genus Momordica as Potential Sources of Phytochemicals: Biochemical, Nutritional, and Medicinal Values

M Muronga, C Quispe, PP Tshikhudo… - Frontiers in …, 2021 - frontiersin.org
Momordica species (Family Cucurbitaceae) are cultivated throughout the world for their
edible fruits, leaves, shoots and seeds. Among the species of the genus Momordica, there …

Novel ACE inhibitory peptides derived from whey protein hydrolysates: Identification and molecular docking analysis

X Li, C Feng, H Hong, Y Zhang, Z Luo, Q Wang, Y Luo… - Food Bioscience, 2022 - Elsevier
Angiotensin I-converting enzyme (ACE) plays a significant role in the regulation of blood
pressure via generating angiotensin II (Ang II). Using natural inhibitors to block the activity of …

Structural-based virtual screening and identification of novel potent antimicrobial compounds against YsxC of Staphylococcus aureus

R Kumari, R Rathi, SR Pathak, V Dalal - Journal of Molecular Structure, 2022 - Elsevier
Ribosome biogenesis GTP-binding (YsxC) is a GTPase, an essential protein involved in
ribosomal assembly and protein synthesis in Staphylococcus aureus. In the current study …

Structure-Based Identification of Potential Drugs Against FmtA of Staphylococcus aureus: Virtual Screening, Molecular Dynamics, MM-GBSA, and QM/MM

V Dalal, P Dhankhar, V Singh, V Singh… - The protein journal, 2021 - Springer
Staphylococcus aureus is resistant to β-lactam antibiotics and causes several skin diseases
to life-threatening diseases. FmtA is found to be one of the main factors involved in …

Characterization of dye-decolorizing peroxidase from Bacillus subtilis

P Dhankhar, V Dalal, JK Mahto, BR Gurjar… - Archives of Biochemistry …, 2020 - Elsevier
The dye-decolorizing peroxidases (DyPs) belong to a unique heme peroxidase family for
their biotechnological potential to detoxify synthetic dyes. In this work, we have …

Identification of potential inhibitors for LLM of Staphylococcus aureus: structure-based pharmacophore modeling, molecular dynamics, and binding free energy …

R Kumari, V Dalal - Journal of Biomolecular Structure and …, 2022 - Taylor & Francis
Staphylococcus aureus causes various life-threatening diseases in humans and developed
resistance to several antibiotics. Lipophilic membrane (LLM) protein regulates bacterial lysis …

Screening and Identification of Natural Product‐Like Compounds as Potential Antibacterial Agents Targeting FemC of Staphylococcus aureus: An in‐Silico Approach

V Dalal, R Kumari - ChemistrySelect, 2022 - Wiley Online Library
FemC is a methicillin resistance factor and regulates the synthesis of peptidoglycan in
Staphylococcus aureus. Here, a set of natural product‐like compounds from Enamine and …

Computational guided identification of novel potent inhibitors of N-terminal domain of nucleocapsid protein of severe acute respiratory syndrome coronavirus 2

P Dhankhar, V Dalal, V Singh, S Tomar… - Journal of Biomolecular …, 2022 - Taylor & Francis
Abstract The Coronavirus Disease 2019, caused by the severe acute respiratory syndrome
coronavirus 2 is an exceptionally contagious disease that leads to global epidemics with …

Structure-based mimicking of hydroxylated biphenyl congeners (OHPCBs) for human transthyretin, an important enzyme of thyroid hormone system

R Kumari, P Dhankhar, V Dalal - Journal of Molecular Graphics and …, 2021 - Elsevier
In humans, transthyretin (hTTR) is a plasma protein act as a transporter of thyroxine (T4) in
the blood. Polychlorinated biphenyls (PCBs) are used in coolants, transformers, plasticizers …