Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Traditional
chemotherapy drugs are hard to reach a satisfactory therapeutic effect since advanced HCC …

Background: Pyrazole scaffolds have gained importance in drug discovery and development
for various pharmacological activities like antiviral, antifungal, anticancer, antidepressant …

Atropisomeric (hetero) biaryls are motifs with increasing significance in ligands, natural
products, and biologically active molecules. The straightforward construction of the …

In-depth study of structure-based drug designing can provide vital leads for the development
of novel, clinically active molecules. In this present study, twenty six novel pyrazolo [1, 5-a] …

A new series of 2-(5-aryl-1-phenyl-1 H-pyrazol-3-yl)-4-aryl thiazoles (10a–ab) have been
synthesized by a cyclocondensation reaction of 5-aryl-1-phenyl-1 H-pyrazole-3 …

In view of the devastating tuberculosis infections and emerging resistance against available
drugs, novel 5-phenyl-3-(thiophen-2-yl)-4, 5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl) …

Introduction Tuberculosis is a global health problem that causes 1. 4 million deaths every
year. It has been estimated that sputum smear-negative diagnosis but culture-positive …

A novel Schiff base named 5-methyl-3-((5-bromosalicylidene) amino)-pyrazole (HMBP) was
synthesized by refluxing of 3-amino-5-methylpyrazole and 5-bromosalicylaldehyde in 1: 1 M …

Tuberculosis remains one of the deadliest infectious diseases in the world, and the
increased number of multidrug-resistant and extremely drug-resistant strains is a significant …

Sodium ascorbate (SA) was used as a safe catalyst for the synthesis of 5-aminopyrazole-4-
carbonitriles from the one-pot three-component cyclocondensation (3-CC) of aldehydes …