Metastasis is a pivotal event that accelerates the prognosis of cancer patients towards
mortality. Therapies that aim to induce cell death in metastatic cells require a more detailed …

Blood vessels are lined by a single layer of endothelial cells that provide a barrier between
circulating plasma and the underlying tissue. Permeability of endothelial cells is tightly …

Endothelial cells (ECs) are constantly submitted in vivo to hemodynamical forces derived
from the blood circulation, including shear stress (SS). ECs are able to detect SS and …

Abstract Blood‐brain‐barrier (BBB) disruption has been associated with a variety of central‐
nervous‐system diseases. In vitro BBB models enable to investigate how the barrier reacts …

Background Plasma gelsolin (pGSN) is an important part of the blood actin buffer that
prevents negative consequences of possible F-actin deposition in the microcirculation and …

Drug development for ischemic stroke is challenging as evidenced by the paucity of
therapeutics that have advanced beyond a phase III trial. There are many reasons for this …

Scaffolds delivered to injured spinal cords to stimulate axon connectivity often match the
anisotropy of native tissue using guidance cues along the rostral-caudal axis, but current …

Physical forces exert profound effects on cells affecting fate, function, and response to
stressors. In the case of the endothelium, the layer that resides in the inner surface of blood …

The endothelial glycocalyx (GCX), located on the luminal surface of vascular endothelial
cells, is composed of glycoproteins, proteoglycans, and glycosaminoglycans. It plays a …

The endothelial glycocalyx is an extracellular matrix that coats the endothelium and extends
into the lumen of blood vessels, acting as a barrier between the vascular wall and blood …