2H/4H-Chromenes—A versatile biologically attractive Scaffold

V Raj, J Lee - Frontiers in Chemistry, 2020 - frontiersin.org
2H/4H-chromene (2H/4H-ch) is an important class of heterocyclic compounds with versatile
biological profiles, a simple structure, and mild adverse effects. Researchers discovered …

Targeted potent antimicrobial and antitumor oxygen-heterocyclic-based pyran analogues: Synthesis and computational studies

AHFA El-Wahab, RM Borik, AAM Al-Dies, AM Fouda… - Scientific Reports, 2024 - nature.com
The process of creating a series of 3-amino-1-aryl-8-methoxy-1 H-benzo [f] chromene-2-
carbonitriles (4a-q) involved reacting 6-methoxynaphthalen-2-ol (1), the appropriate …

An insight into the synthesis and SAR of 2, 4-Thiazolidinediones (2, 4-TZD) as Multifunctional scaffold: A review

NS Sethi, DN Prasad, RK Singh - Mini Reviews in Medicinal …, 2020 - ingentaconnect.com
2, 4-Thiazolidinedione (2, 4-TZD) is a versatile pharmacophore, a privileged scaffold, and a
remarkable sulphur-containing heterocyclic compound with diverse pharmacological …

Design, synthesis, antimicrobial activity and computational studies of novel azo linked substituted benzimidazole, benzoxazole and benzothiazole derivatives

VR Mishra, CW Ghanavatkar, SN Mali… - … biology and chemistry, 2019 - Elsevier
Novel azo linked substituted benzimidazole, benzoxazole, and benzothiazole were
synthesized by diazo coupling and characterized by 1 H NMR, elemental analysis, FTIR and …

Determination of potential inhibitors based on isatin derivatives against SARS-CoV-2 main protease (mpro): a molecular docking, molecular dynamics and structure …

VN Badavath, A Kumar, PK Samanta… - Journal of …, 2022 - Taylor & Francis
Abstract SARS-COV-2, the novel coronavirus and root of global pandemic COVID-19
caused a severe health threat throughout the world. Lack of specific treatments raised an …

Discovery of benzochromene derivatives first example with dual cytotoxic activity against the resistant cancer cell MCF-7/ADR and inhibitory effect of the P …

LM Al-Harbi, EA Al-Harbi, RM Okasha… - Journal of Enzyme …, 2023 - Taylor & Francis
A series of 1 H-benzo [f] chromene moieties (4a–z) were synthesised under Ultrasonic
irradiation and confirmed with spectral analyses. Derivative 4i solely possessed an X-ray …

Synthesis, characterization, anti-proliferative properties and DNA binding of benzochromene derivatives: Increased Bax/Bcl-2 ratio and caspase-dependent apoptosis …

MH Ahagh, G Dehghan, M Mehdipour… - Bioorganic …, 2019 - Elsevier
Amino-1-aryl-1H-benzo [f] chromene-2-carbonitrile derivatives were synthesized from three-
component reaction of arylaldehyde, malononitrile and 2-naphthol in the presence of 1, 4 …

Antifungal and antibiofilm activities of chromones against nine Candida species

JH Lee, YG Kim, Y Kim, J Lee - Microbiology Spectrum, 2023 - journals.asm.org
Candida species are the most common cause of fungal infections, and thus the emergence
of antifungal-resistant species and biofilm formation by Candida further threatens the limited …

Antiproliferative effect, cell cycle arrest and apoptosis generation of novel synthesized anticancer heterocyclic derivatives based 4H-benzo [h] chromene

FF Alblewi, RM Okasha, ZM Hritani, HM Mohamed… - Bioorganic …, 2019 - Elsevier
Novel β-enaminonitrile/ester compounds (4, 6) and an imidate of 4 (9) were utilized as key
scaffolds for the synthesis of newly 2-substituted 4H-benzo [h] chromene (7, 8, 10, 11, 13 …

[HTML][HTML] Synthesis and Evaluation of Some New 4H-Pyran Derivatives as Antioxidant, Antibacterial and Anti-HCT-116 Cells of CRC, with Molecular Docking …

NNE El-Sayed, MEA Zaki, SA Al-Hussain… - Pharmaceuticals, 2022 - mdpi.com
Colorectal cancer oncogenesis is linked to dysbiosis, oxidative stress and overexpression of
CDK2. The 4 H-pyran scaffold is considered an antitumoral, antibacterial and antioxidant …