Ferroptosis in cancer: From molecular mechanisms to therapeutic strategies

Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - … and Targeted Therapy, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …

Iron‐MOFs for Biomedical Applications

Z Yu, M Lepoitevin, C Serre - Advanced Healthcare Materials, 2024 - Wiley Online Library
Over the past two decades, iron‐based metal–organic frameworks (Fe‐MOFs) have
attracted significant research interest in biomedicine due to their low toxicity, tunable …

Progress and challenges in tumor ferroptosis treatment strategies: a comprehensive review of metal complexes and nanomedicine

Y Su, B Liu, B Wang, L Chan, C **ong, L Lu, X Zhang… - Small, 2024 - Wiley Online Library
Ferroptosis is a new form of regulated cell death featuring iron‐dependent lipid peroxides
accumulation to kill tumor cells. A growing body of evidence has shown the potential of …

Tetrahydrobiopterin inhibitor-based antioxidant metabolic strategy for enhanced cancer ferroptosis-immunotherapy

Z Liu, R Kang, N Yang, X Pan, J Yang, H Yu… - Journal of Colloid and …, 2024 - Elsevier
The induction of immunogenic ferroptosis in cancer cell is limited by the complex and
delicate antioxidant system in the organism. Synergistic induction of oxidative damage and …

[HTML][HTML] Pharmacological inhibition of SREBP1 suppresses pancreatic cancer growth via inducing GPX4-mediated ferroptosis

R Cao, Z Feng, J Mo, J Wu, J Li, W Li, Z Wang, Q Ma… - Cellular …, 2024 - Elsevier
Pancreatic cancer (PC) is highly malignancy with poor survival. Ferroptosis offers a novel
therapeutic target for cancer treatment and glutathione peroxidase 4 (GPX4) shields tumor …

Glutathione‐Depleted Photodynamic Nanoadjuvant for Triggering Nonferrous Ferroptosis to Amplify Radiotherapy of Breast Cancer

J Shi, G Cui, Y **, B Mi, K Liu, L Zhao… - Advanced …, 2024 - Wiley Online Library
Radiotherapy plays a crucial role in the treatment of advanced breast cancer, but the
increased antioxidant system, especially the rise in glutathione (GSH), presents a significant …

Lipid Nanoparticular Codelivery System for Enhanced Antitumor Effects by Ferroptosis–Apoptosis Synergistic with Programmed Cell Death-Ligand 1 Downregulation

W Cao, X Zhang, Y Feng, R Li, A Lu, Z Li, F Yu, L Sun… - ACS …, 2024 - ACS Publications
Intrinsic or acquired resistance to chemical drugs severely limits their therapeutic efficacy in
cancer treatment. Various intracellular antioxidant molecules, particularly glutathione (GSH) …

Intelligent Micro/nanorobots Based on Biotemplate

T Chen, Y Cai, B Ren, BJ Sánchez, R Dong - Materials horizons, 2024 - pubs.rsc.org
Intelligent micro/nanorobots based on natural materials as biotemplates are considered to
be some of the most promising robots in the future in the microscopic field. Due to the …

Carrier-free nanoparticles based on self-assembly of 5-FU and copper-genistein complexes for the combined treatment of hepatocellular carcinoma

S Chen, H Huang, Q Li, J Cai, Z Miao, P **e… - Drug Delivery and …, 2024 - Springer
Fluorouracil (5-FU) is commonly used as a chemotherapeutic drug for advanced HCC.
However, the effectiveness of 5-FU is limited by the emergence of resistance and poor …

[HTML][HTML] Cell death mechanisms in human cancers: Molecular pathways, therapy resistance and therapeutic perspective

M Ashrafizadeh - Journal of Cancer Biomoleculars and …, 2024 - jcbt.eternopublisher.com
A prominent cause of death among patients is cancer that can result from somatic mutations
and exposure to environmental factors, among others. The treatment of cancer has been …